{"DOI":"10.1038/s41467-020-20588-0","PMID":"33436622","abstract":"AbstractThe transmembrane P-glycoprotein (P-gp) pumps that efflux drugs are a major mechanism of cancer drug resistance. They are also important in protecting normal tissue cells from poisonous xenobiotics and endogenous metabolites. Here, we report a fucoidan-decorated silica-carbon nano-onion (FSCNO) hybrid nanoparticle that targets tumor vasculature to specifically release P-gp inhibitor and anticancer drug into tumor cells. The tumor vasculature targeting capability of the nanoparticle is demonstrated using multiple models. Moreover, we reveal the superior light absorption property of nano-onion in the near infrared region\u00a0(NIR), which enables triggered drug release from the nanoparticle at a low NIR power. The released inhibitor selectively binds to P-gp pumps\u00a0and disables their function, which improves the bioavailability of anticancer drug inside the cells. Furthermore, free P-gp inhibitor significantly increases the systemic toxicity of a chemotherapy drug, which can be resolved by delivering them with FSCNO nanoparticles in combination with a\u00a0short low-power NIR laser irradiation.","author":[{"family":"Wang","given":"Hai"},{"family":"Liang","given":"Yutong"},{"family":"Yin","given":"Yue"},{"family":"Zhang","given":"Jie"},{"family":"Su","given":"Wen"},{"family":"White","given":"Alisa M."},{"family":"Bin Jiang"},{"family":"Xu","given":"Jiangsheng"},{"family":"Zhang","given":"Yuntian"},{"family":"Stewart","given":"Samantha"},{"family":"Lu","given":"Xiongbin"},{"family":"He","given":"Xiaoming"}],"id":"unknown","issue":"1","issued":{"date-parts":[[2021,1,12]]},"language":"en","page-first":"312","publisher":"Springer Science and Business Media LLC","title":"Carbon nano-onion-mediated dual targeting of P-selectin and P-glycoprotein to overcome cancer drug resistance","type":"article-journal","volume":"12"}