Prevalence of multimorbid degenerative lumbar spinal stenosis with knee and/or hip osteoarthritis: protocol for a systematic review and meta-analysis release_zgfiygmuxjh6bi7zhqptu622ky

by James J. Young, Jan Hartvigsen, Rikke K. Jensen, Ewa M. Roos, Carlo Ammendolia, Carsten Bogh Juhl

Released as a post by Research Square.

2020  

Abstract

<jats:title>Abstract</jats:title> <jats:bold>Background: </jats:bold>Lumbar spinal stenosis (LSS) and knee and hip osteoarthritis (OA) are prevalent conditions in the aging population and published literature suggests they share many symptoms and often are present at the same time in patients. However, no prevalence estimates of multimorbid LSS and knee and/or hip OA are currently available.<jats:bold> </jats:bold>The primary objective of this systematic review is therefore to estimate the prevalence of multimorbid LSS with knee and/or hip OA using radiological, clinical, and combined case definitions. <jats:bold>Methods: </jats:bold>This systematic review protocol has been designed according to the guidelines from the Cochrane Collaboration and are reported according the Preferred Reporting Items for Systematic Reviews and Meta-Analysis Protocols. A comprehensive search will be performed in the following databases: MEDLINE, EMBASE, CENTRAL, and CINAHL. Forward citation tracking will be performed in Web of Science. No restriction for publication data and language will be applied in the literature search, but only articles in English will be included. The search strategy will include the following domains: LSS, knee OA, and hip OA. Retrieved citations will be screened by two authors independently. Disagreements will be discussed until consensus, and a third reviewer will be consulted if consensus cannot be reached. Data extraction and assessment of methodological quality will be done by two authors independently, using a standardized data extraction form and a modified Risk of Bias Tool for Prevalence studies. Meta-analysis estimating prevalence with 95% CI will be performed using a random effects model. Meta-regression analyses will be performed to investigate the impact of the following covariates: LSS clinical presentations, sample population, healthcare setting, risk of bias, and other patient characteristics on prevalence estimates for multimorbid LSS and knee and/or hip OA.<jats:bold>Discussion: </jats:bold>The results of this review will provide the first estimates of the prevalence of multimorbid LSS and hip and knee OA based on various case definitions. The impact of covariates such as LSS clinical presentations, sample population, healthcare setting, risk of bias, and patient characteristics on prevalence estimates will also be presented. <jats:bold>Systematic review registration: </jats:bold>Submitted to PROSPERO, awaiting registration
In application/xml+jats format

Archived Files and Locations

application/pdf  385.8 kB
file_7eku3oqkr5ahrkfamffton466y
assets.researchsquare.com (publisher)
web.archive.org (webarchive)
application/pdf  791.1 kB
file_wn5sdcdee5hudk2keccxmm6rcy
findresearcher.sdu.dk:8443 (web)
web.archive.org (webarchive)
Read Archived PDF
Preserved and Accessible
Type  post
Stage   unknown
Date   2020-08-10
Work Entity
access all versions, variants, and formats of this works (eg, pre-prints)
Catalog Record
Revision: 3862b023-5f8c-4897-a81b-f5b5fc50b291
API URL: JSON