@article{wang_zhao_lou_morris-natschke_li_yang_shi_lee_tokuda_2014, title={Total synthesis of plagiochin G and derivatives as potential cancer chemopreventive agents}, DOI={10.17615/fx27-fx23}, abstractNote={A new and efficient total synthesis has been developed to obtain plagiochin G (22), a macrocyclic bisbibenzyl, and four derivatives. The key 16-membered ring containing biphenyl ether and biaryl units was closed via an intramolecular SNAr reaction. All synthesized macrocyclic bisbibenzyls inhibited Epstein-Barr virus early antigen (EBVEA) activation induced by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells and, thus, are potential cancer chemopreventive agents.}, publisher={The University of North Carolina at Chapel Hill University Libraries}, author={Wang and Zhao and Lou and Morris-Natschke and Li and Yang and Shi and Lee and Tokuda}, year={2014} }