Cancer Risks for PMS2-Associated Lynch Syndrome release_ygv6z7uhcrclxfwx5ugc3o3tee

by Sanne W. ten Broeke, Heleen M. van der Klift, Carli M.J. Tops, Stefan Aretz, Inge Bernstein, Daniel D. Buchanan, Albert de la Chapelle, Gabriel Capella, Mark Clendenning, Christoph Engel, Steven Gallinger, Encarna Gomez Garcia (+36 others)

Published in Journal of Clinical Oncology by American Society of Clinical Oncology (ASCO).

2018   Volume 36, Issue 29, JCO.2018.78.477

Abstract

Heterozygous PMS2 mutation carriers were at small increased risk for colorectal and endometrial cancer but not for any other Lynch syndrome-associated cancer. This finding justifies that PMS2-specific screening protocols could be restricted to colonoscopies. The role of risk-reducing hysterectomy and bilateral salpingo-oophorectomy for PMS2 mutation carriers needs further discussion.
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Type  article-journal
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Date   2018-08-30
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