Are Absence Epilepsy and Nocturnal Frontal Lobe Epilepsy System Epilepsies of the Sleep/Wake System? release_y2iqefwoqbettmyp6rss3wtpwu

by Péter Halász

Published in Behavioural Neurology by Hindawi Limited.

2015   Volume 2015, p1-15

Abstract

System epilepsy is an emerging concept interpreting major nonlesional epilepsies as epileptic dysfunctions of physiological systems. I extend here the concept of reflex epilepsy to epilepsies linked to input dependent physiological systems. Experimental and clinical reseach data were collected to create a coherent explanation of underlying pathomechanism in AE and NFLE. We propose that AE should be interpreted as epilepsy linked to the corticothalamic burst-firing mode of NREM sleep, released by evoked vigilance level oscillations characterized by reactive slow wave response. In the genetic variation of NFLE the ascending cholinergic arousal system plays an essential role being in strong relationship with a gain mutation of the nicotinic acethylcholin receptors, rendering the arousal system hyperexcitable. I try to provide a more unitary interpretation for the variable seizure manifestation integrating them as different degree of pathological arosuals and alarm reactions. As a supporting hypothesis the similarity between arousal parasomnias and FNLE is shown, underpinned by overlaping pathomechanism and shared familiarity, but without epileptic features. Lastly we propose that both AE and NFLE are system epilepsies of the sleep-wake system representing epileptic disorders of the antagonistic sleep/arousal network. This interpretation may throw new light on the pathomechanism of AE and NFLE.
In application/xml+jats format

Archived Files and Locations

application/pdf  4.2 MB
file_57fnir65qngfpioqxxy2ae2dcy
downloads.hindawi.com (publisher)
web.archive.org (webarchive)
application/pdf  3.4 MB
file_aagvmvn5hbfzbemvnctmfisy3a
web.archive.org (webarchive)
pdfs.semanticscholar.org (aggregator)
Read Archived PDF
Preserved and Accessible
Type  article-journal
Stage   published
Year   2015
Language   en ?
DOI  10.1155/2015/231676
PubMed  26175547
PMC  PMC4484558
Wikidata  Q26801722
Container Metadata
Open Access Publication
In DOAJ
In Keepers Registry
ISSN-L:  0953-4180
Work Entity
access all versions, variants, and formats of this works (eg, pre-prints)
Catalog Record
Revision: 579c4a3a-a66c-41ba-a482-28a6308e89b1
API URL: JSON