The Yersinia pestis GTPase BipA Promotes Pathogenesis of Primary Pneumonic Plague release_xxucswcpgzbp5mr6oqdc2z5s74

by Samantha D. Crane, Srijon K. Banerjee, Kara R. Eichelberger, Richard C. Kurten, William E. Goldman, Roger Pechous

Published in Infection and Immunity by American Society for Microbiology.

2020   Volume 89

Abstract

<jats:title>ABSTRACT</jats:title> <jats:named-content content-type="genus-species">Yersinia pestis</jats:named-content> is a highly virulent pathogen and the causative agent of bubonic, septicemic, and pneumonic plague. Primary pneumonic plague caused by inhalation of respiratory droplets contaminated with <jats:named-content content-type="genus-species">Y. pestis</jats:named-content> is nearly 100% lethal within 4 to 7 days without antibiotic intervention. Pneumonic plague progresses in two phases, beginning with extensive bacterial replication in the lung with minimal host responsiveness, followed by the abrupt onset of a lethal proinflammatory response. The precise mechanisms by which <jats:named-content content-type="genus-species">Y. pestis</jats:named-content> is able to colonize the lung and survive two very distinct disease phases remain largely unknown. To date, a few bacterial virulence factors, including the Ysc type 3 secretion system, are known to contribute to the pathogenesis of primary pneumonic plague. The bacterial GTPase BipA has been shown to regulate expression of virulence factors in a number of Gram-negative bacteria, including <jats:named-content content-type="genus-species">Pseudomonas aeruginosa</jats:named-content>, <jats:named-content content-type="genus-species">Escherichia coli</jats:named-content>, and <jats:named-content content-type="genus-species">Salmonella enterica</jats:named-content> serovar Typhi. However, the role of BipA in <jats:named-content content-type="genus-species">Y. pestis</jats:named-content> has yet to be investigated. Here, we show that BipA is a <jats:named-content content-type="genus-species">Y. pestis</jats:named-content> virulence factor that promotes defense against early neutrophil-mediated bacterial killing in the lung. This work identifies a novel <jats:named-content content-type="genus-species">Y. pestis</jats:named-content> virulence factor and highlights the importance of early bacterial/neutrophil interactions in the lung during primary pneumonic plague.
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