The impact of generic form of Clopidogrel on cardiovascular events in patients with coronary artery stent: results of the OPCES study release_xq3qg22ibfgt7c2afagfupwydq

by Ali Reza Khosravi, Masoud Pourmoghadas, Mohammad Ostovan, Gilda Kiani Mehr, Mojgan Gharipour, Habib Zakeri, Bahram Soleimani, Mehrdad Namdari, Mehdi Hassanzadeh, Ali Akbar Tavassoli, Samad Ghaffari, Arsalan Khaledifar (+8 others)

Published in Journal of Research in Medical Sciences.

2011   Volume 16, Issue 5, p640-50

Abstract

To compare the early and late cardiovascular events as well as side effects of Osvix, a generic form of Clopidogrel versus Plavix regimens in patients with chronic stable angina, undergoing bare metal stent (BMS) or drug eluting stent (DES) placement, this study was carried out. A total of 442 patients with chronic stable angina who were scheduled for elective percutaneous coronary intervention (PCI) were included in a randomized, double blind, multi-centric clinical trial being performed in 6 distinct university hospitals in 5 cities of Iran from March 2007 to November 2009. Baseline, demographic and history of risk factors were recorded using the patients' medical charts. Stenting procedure was performed via transfemoral approach using low osmolar contrast agents. Patients underwent BMS or DES placements based on the physician selection and were randomly assigned to Osvix or Plavix groups. Patients were followed by telephone in 0 and 6 months intervals regarding the major adverse cardiovascular events (MACE) including death, myocardial infarction, in-stent thrombosis, stroke, target lesion revascularization, and target vascular revascularization. Angina episodes, bleeding, liver enzymes, neutrophils and platelets count were also assessed in these intervals. There was not any significant difference between these two groups regarding the baseline characteristics. In the DES group, the 6-month mortality rate and the incidence of MACE in Osvix and Plavix groups were 0.9% and 1.9% (p = 0.61) and 1.8% and 4.9% (p = 0.26), respectively. During the follow up period after DES or BMS placement, there wasn't any significant difference regarding neutrophil and platelet counts or liver enzymes between study groups. Using Osvix and Plavix are followed by similar major cardiovascular events and side-effect profile in patients undergoing PCI.
In text/plain format

Archived Files and Locations

application/pdf  237.6 kB
file_kaseeijqubgnjaf4jivvf6vnui
doc.mui.ac.ir (web)
web.archive.org (webarchive)
Read Archived PDF
Archived
Type  article-journal
Stage   published
Year   2011
Language   en ?
PubMed  22091287
PMC  PMC3214376
Journal Metadata
Open Access Publication
In DOAJ
In ISSN ROAD
In Keepers Registery
ISSN-L:  1735-1995
Work Entity
access all versions, variants, and formats of this works (eg, pre-prints)
Catalog Record
Revision: 9e7cfc71-16ea-4d5a-a02c-25fd4338a818
API URL: JSON