Harnessing the power of transition metals in solid-phase peptide synthesis and key steps in the (semi)synthesis of proteins
Gandhesiri Satish Shay Laps
Peptides and proteins can be either synthesized using solid-phase peptide synthesis (SPPS) or by<br> applying a combination of SPPS and ligation approaches to address fundamental questions related to<br> human health and disease, among others. The demand for their production either by chemical or<br> biological methods continues to raise significant interests from the synthetic community. In this context,<br> transition metals such as Pd, Ag, Hg, Tl, Au, Zn, Ni, and Cu have also contributed to the field of peptide<br> and protein synthesis such as in peptide conjugation, extending native chemical ligation (NCL), and for<br> regioselective disulfide bonds formation. In this review, we highlight, summarize, and evaluate the use of<br> various transition metals in the chemical synthesis of peptides and proteins with emphasis on recent<br> developments in this exciting research area.
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