@misc{capogrosso_barra_conti_perich_zhuang_schiavone_fallegger_galan_james_barraud_et al._2021,
title={Epidural Electrical Stimulation Of The Cervical Dorsal Roots Restores Voluntary Arm Control In Paralyzed Monkeys},
DOI={10.21203/rs.3.rs-395156/v1},
abstractNote={Abstract
Recovering arm control is a top priority for people with paralysis. Unfortunately, the complexity of the neural mechanisms underlying arm control practically limited the effectiveness of neurotechnology approaches. Here, we exploited the neural function of surviving spinal circuits to restore voluntary arm and hand control in three monkeys with spinal cord injury using spinal cord stimulation. Our neural interface leverages the functional organization of the dorsal roots to convey artificial excitation via electrical stimulation to relevant spinal segments at appropriate movement phases. Stimulation bursts, triggered by intracortical signals produced sustained arm movements enabling monkeys with arm paralysis to perform an unconstrained, three-dimensional reach-and-grasp task. Stimulation specifically improved strength, task performances and movement quality. Electrophysiology suggested that artificial recruitment of the sensory afferents was synergistically integrated with spared descending inputs and spinal reflexes to produce coordinated movements. The efficacy and reliability of our approach hold realistic promises of clinical translation.},
publisher={Research Square Platform LLC},
author={Capogrosso, Marco and Barra, Beatrice and Conti, Sara and Perich, Matthew and Zhuang, Katie and Schiavone, Giuseppe and Fallegger, Florian and Galan, Katia and James, Nicholas and Barraud, Quentin and et al.},
year={2021},
month={Apr}
}