Nanocomposites Based on PLLA and Multi Walled Carbon Nanotubes Support the Myogenic Differentiation of Murine Myoblast Cell Line release_xiw43wi365ftbaiboiuglydaim

by Simona Montesano, Erlantz Lizundia, Francesco D'Angelo, Elena Fortunati, Samantha Mattioli, Francesco Morena, Ilaria Bicchi, Fabio Naro, Maurilio Sampaolesi, Josè Ramon Sarasua, Josè Maria Kenny, Aldo Orlacchio (+2 others)

Published in ISRN Tissue Engineering by Hindawi Limited.

2013   Volume 2013, p1-8


We explored the effect of poly(L-lactic acid) (PLLA) containing various percentages (0.1, 0.5, 1, and 3 wt.%) of multi walled carbon nanotubes (MWCNTs) on the myogenic differentiation of C2C12 murine myoblast progenitor cells. We showed that all PLLA/MWCNTs nanocomposite materials support the myotubes formation more efficiently than neat PLLA as indicated by the high expression of the most significant myogenic markers: MyoD, Myosin Heavy Chain, dimension of myofibres, and fusion myogenic index. Interestingly, we note that both MyoD and myogenic fusion index levels were in the order 0.1 MWCNTs = 0.5 MWCNTs > 1 MWCNTs > 3 MWCNTs > neat PLLA, suggesting that the amount of MWCNTs influenced the cell differentiation.
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Type  article-journal
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Year   2013
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ISSN-L:  2314-4696
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