Systemic inflammatory response to cardiac surgery: does female sex really protect? release_xh2tcyd26jgltm5notg5ixekl4

by M C Seghaye, M Qing, G von Bernuth

Abstract

Sex hormones have important interactions with the immune system and modulate the inflammatory response. In this regard, oestrogen inhibits the transcription of proinflammatory cytokines and confers tissue protection in experimental models. On the basis of this evidence, Trotter et al. in this issue of Critical Care addressed the question of whether, in children, female sex would protect against the deleterious effects of cardiac operations with cardiopulmonary bypass by providing a favourable anti-inflammatory cytokine balance. The observations made in that study suggest sex-related immunomodulation and organ protection during cardiac surgery in the paediatric population. Prospective trials conducted in large series, including sex hormone determination in neonates, infants and children with congenital cardiac defects, are necessary to test this hypothesis. The verification of sex-related intraoperative organ protection would provide new opportunities for preventing the uncontrolled systemic inflammatory response that may occur during cardiac surgery.
In text/plain format

Published in Critical Care
ISSN-L 1364-8535
Volume 5
Issue 6
Page(s) 280-2
Release Date 2001-11-06
Primary Language en (lookup)

Known Files and URLs

application/pdf  116.6 kB
sha1:74367242b60cc3cfb9e9...
web.archive.org (webarchive)
link.springer.com (publisher)
Read Full Text
Type  article-journal
Stage   published
Date   2001-11-06
PubMed  11737904
PMC  PMC137366
Container Metadata
Open Access Publication
In DOAJ
Not in ISSN ROAD
In Keepers Registery
ISSN-L:  1364-8535
Fatcat Entry
Work Entity
grouping other versions (eg, pre-print) and variants of this release
Cite This Release
Fatcat Bits

State is "active". Revision:
9679d0d6-5d1e-45dd-a6d5-8a588b15af00
As JSON object via API