Rodents as a model for functional connectivity in humans release_xgumowk7affwtgiidlolbe3x2u

by Nan Xu, Theodore J. LaGrow, Nmachi Anumba, Xiaodi Zhang, Behnaz Yousefi, Azalea Lee, Yasmine Bassil, Gloria Perrin Clavijo, Vahid Khalilzad, Eric Maltbie, Lisa Meyer-Baese, Maysam Nezafati (+3 others)

Released as a article .

2021  

Abstract

Resting-state functional magnetic resonant imaging (rs-fMRI) is increasingly utilized for the investigation of normal and pathological brain activity. Rodent models play a key role in neuroscience research and neuroimaging studies that examine the neurophysiology that underpins the spontaneous fluctuations in the blood oxygenation level dependent (BOLD) signal, but translating this knowledge to humans assumes that both the BOLD fluctuations and the underlying neurophysiology are similar across species. This review begins by examining similarities and differences in anatomical features, acquisition parameters, and preprocessing techniques. Common functional networks are compared across species, and aspects of the BOLD fluctuations such as the topography of the global signal and the relationship between structural and functional connectivity are examined. The results of time-varying analysis methods, including windowed approaches, quasi-periodic patterns, and coactivation patterns, are compared across species. Applications demonstrating the use of rs-fMRI as a translational tool for cross-species analysis are discussed, with an emphasis on neurological and psychiatric disorders. Finally, open questions are presented to encapsulate the future direction of the field.
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Type  article
Stage   submitted
Date   2021-11-10
Version   v1
Language   en ?
arXiv  2111.05912v1
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