Rodents as a model for functional connectivity in humans
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by
Nan Xu, Theodore J. LaGrow, Nmachi Anumba, Xiaodi Zhang, Behnaz Yousefi, Azalea Lee, Yasmine Bassil, Gloria Perrin Clavijo, Vahid Khalilzad, Eric Maltbie, Lisa Meyer-Baese, Maysam Nezafati (+3 others)
2021
Abstract
Resting-state functional magnetic resonant imaging (rs-fMRI) is increasingly
utilized for the investigation of normal and pathological brain activity.
Rodent models play a key role in neuroscience research and neuroimaging studies
that examine the neurophysiology that underpins the spontaneous fluctuations in
the blood oxygenation level dependent (BOLD) signal, but translating this
knowledge to humans assumes that both the BOLD fluctuations and the underlying
neurophysiology are similar across species. This review begins by examining
similarities and differences in anatomical features, acquisition parameters,
and preprocessing techniques. Common functional networks are compared across
species, and aspects of the BOLD fluctuations such as the topography of the
global signal and the relationship between structural and functional
connectivity are examined. The results of time-varying analysis methods,
including windowed approaches, quasi-periodic patterns, and coactivation
patterns, are compared across species. Applications demonstrating the use of
rs-fMRI as a translational tool for cross-species analysis are discussed, with
an emphasis on neurological and psychiatric disorders. Finally, open questions
are presented to encapsulate the future direction of the field.
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