Nasal high flow improves ventilation during propofol sedation: A randomized cross-over study in healthy volunteers release_wo4buqgqdjf3jpij2dnhfko7vm

by Gaku Mishima, Takuro Sanuki, James Revie, Max Pinkham, Toshihiro Watanabe, Shinji Kurata, Stanislav Tatkov, Takao Ayuse

Published in Respiratory Physiology & Neurobiology by Elsevier BV.

2020   p103429


Hypoventilation and carbon dioxide (CO2) retention are common during sedation. The current study investigated the ventilation responses to nasal high flow (NHF) during sedation with propofol. NHF of 30 L/min and 60 L/min with room air was applied during wakefulness and sedation in 10 male volunteers. Ventilation was monitored by respiratory inductance plethysmography, transcutaneous partial pressure of CO2 (TcCO2), and SpO2. During sedation, NHF of 30 L/min and 60 L/min reduced the TcCO2 by 2.9 ± 2.7 mmHg (p = 0.025) and by 3.6 ± 3.4 mmHg (p = 0.024) without affecting SpO2 and reduced the mean respiratory rate by 3 ± 3 breaths/min (p = 0.011) and by 4 ± 3 breaths/min (p = 0.003), respectively. During sedation with propofol, NHF without supplemental oxygen attenuated CO2 retention and reduced the respiratory rate. The findings show that NHF can improve ventilation during sedation, which may reduce the risk of complications related to hypoventilation.
In text/plain format

Archived Files and Locations

application/pdf  847.2 kB
file_mvoilnz2dnf2rabdrguyieaode (web) (webarchive)
application/pdf  352.4 kB
file_sipklnc3ffdwlhglgbzdhpvjra (web) (webarchive)
application/pdf  840.6 kB
file_f45gp7sdwvfdvkpvvx52b3podq (web) (webarchive)
application/pdf  311.2 kB
file_mnhnjgevznciljyvpbynnx3coq (web) (webarchive)
Read Archived PDF
Preserved and Accessible
Type  article-journal
Stage   published
Date   2020-03-12
Language   en ?
Container Metadata
Not in DOAJ
In Keepers Registry
ISSN-L:  1569-9048
Work Entity
access all versions, variants, and formats of this works (eg, pre-prints)
Catalog Record
Revision: 553f7539-8ae3-4b04-b5e5-066d8f9049e7