Thymus Degeneration and Regeneration
release_wa7tvc7tsbeqxfig5irni6frpm
by
Maxwell Duah, Lingling Li, Jingyi Shen, Qiu Lan, Bin Pan, Kailin Xu
Abstract
The immune system's ability to resist the invasion of foreign pathogens and the tolerance to self-antigens are primarily centered on the efficient functions of the various subsets of T lymphocytes. As the primary organ of thymopoiesis, the thymus performs a crucial role in generating a self-tolerant but diverse repertoire of T cell receptors and peripheral T cell pool, with the capacity to recognize a wide variety of antigens and for the surveillance of malignancies. However, cells in the thymus are fragile and sensitive to changes in the external environment and acute insults such as infections, chemo- and radiation-therapy, resulting in thymic injury and degeneration. Though the thymus has the capacity to self-regenerate, it is often insufficient to reconstitute an intact thymic function. Thymic dysfunction leads to an increased risk of opportunistic infections, tumor relapse, autoimmunity, and adverse clinical outcome. Thus, exploiting the mechanism of thymic regeneration would provide new therapeutic options for these settings. This review summarizes the thymus's development, factors causing thymic injury, and the strategies for improving thymus regeneration.
In application/xml+jats
format
Archived Files and Locations
application/pdf 1.3 MB
file_ik5xoliqrjdlzjphuoufrujcpq
|
fjfsdata01prod.blob.core.windows.net (publisher) web.archive.org (webarchive) |
Web Captures
https://www.frontiersin.org/articles/10.3389/fimmu.2021.706244/full
2022-06-23 12:19:01 | 31 resources webcapture_hfvziaunmzg6dademweqv2vjem
|
web.archive.org (webarchive) |
Open Access Publication
In DOAJ
In ISSN ROAD
In Keepers Registry
ISSN-L:
1664-3224
access all versions, variants, and formats of this works (eg, pre-prints)
Crossref Metadata (via API)
Worldcat
SHERPA/RoMEO (journal policies)
wikidata.org
CORE.ac.uk
Semantic Scholar
Google Scholar