Discovery and validation of a prognostic proteomic signature for tuberculosis progression: A prospective cohort study release_voyzb2wr2zfy5grg5rik42tmiq

by Adam Penn-Nicholson, Thomas Hraha, Ethan G. Thompson, David Sterling, Stanley Kimbung Mbandi, Kirsten M. Wall, Michelle Fisher, Sara Suliman, Smitha Shankar, Willem A. Hanekom, Nebojsa Janjic, Mark Hatherill (+7 others)

Abstract

Both proteomic TB risk signatures predicted progression to incident TB within a year of diagnosis. To our knowledge, these are the first validated prognostic proteomic signatures. Neither meet the minimum criteria as defined in the WHO Target Product Profile for a progression test. More work is required to develop such a test for practical identification of individuals for investigation of incipient, subclinical, or active TB disease for appropriate treatment and care.
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Published in PLoS Medicine by Public Library of Science (PLoS)
ISSN-L 1549-1277
Volume 16
Issue 4
Page(s) e1002781
Release Date 2019-04-16
Container Type journal
Publisher Public Library of Science (PLoS)
Primary Language en (lookup)

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