fatcat! About Guide Changelog
Login/Signup

Associations between arterial stiffening and brain structure, perfusion, and cognition in the Whitehall II Imaging Sub-study: A retrospective cohort study release_vnf4556zcjfqfmtdnfzzuw5wzm

by Sana Suri, Scott T Chiesa, Enikő Zsoldos, Clare E Mackay, Nicola Filippini, Ludovica Griffanti, Abda Mahmood, Archana Singh-Manoux, Martin J Shipley, Eric J Brunner, Mika Kivimäki, John E Deanfield (+1 others)

Entity Metadata (schema)

abstracts [{'sha1': '0223f2982360b8fed672cdc0b53b4188dcff7c55', 'content': 'Aortic stiffness is closely linked with cardiovascular diseases (CVDs), but recent studies suggest that it is also a risk factor for cognitive decline and dementia. However, the brain changes underlying this risk are unclear. We examined whether aortic stiffening during a 4-year follow-up in mid-to-late life was associated with brain structure and cognition in the Whitehall II Imaging Sub-study.\nThe Whitehall II Imaging cohort is a randomly selected subset of the ongoing Whitehall II Study, for which participants have received clinical follow-ups for 30 years, across 12 phases. Aortic pulse wave velocity (PWV) was measured in 2007-2009 (Phase 9) and at a 4-year follow-up in 2012-2013 (Phase 11). Between 2012 and 2016 (Imaging Phase), participants received a multimodal 3T brain magnetic resonance imaging (MRI) scan and cognitive tests. Participants were selected if they had no clinical diagnosis of dementia and no gross brain structural abnormalities. Voxel-based analyses were used to assess grey matter (GM) volume, white matter (WM) microstructure (fractional anisotropy (FA) and diffusivity), white matter lesions (WMLs), and cerebral blood flow (CBF). Cognitive outcomes were performance on verbal memory, semantic fluency, working memory, and executive function tests. Of 542 participants, 444 (81.9%) were men. The mean (SD) age was 63.9 (5.2) years at the baseline Phase 9 examination, 68.0 (5.2) at Phase 11, and 69.8 (5.2) at the Imaging Phase. Voxel-based analysis revealed that faster rates of aortic stiffening in mid-to-late life were associated with poor WM microstructure, viz. lower FA, higher mean, and radial diffusivity (RD) in 23.9%, 11.8%, and 22.2% of WM tracts, respectively, including the corpus callosum, corona radiata, superior longitudinal fasciculus, and corticospinal tracts. Similar voxel-wise associations were also observed with follow-up aortic stiffness. Moreover, lower mean global FA was associated with faster rates of aortic stiffening (B = -5.65, 95% CI -9.75, -1.54, Bonferroni-corrected p < 0.0125) and higher follow-up aortic stiffness (B = -1.12, 95% CI -1.95, -0.29, Bonferroni-corrected p < 0.0125). In a subset of 112 participants who received arterial spin labelling scans, faster aortic stiffening was also related to lower cerebral perfusion in 18.4% of GM, with associations surviving Bonferroni corrections in the frontal (B = -10.85, 95% CI -17.91, -3.79, p < 0.0125) and parietal lobes (B = -12.75, 95% CI -21.58, -3.91, p < 0.0125). No associations with GM volume or WMLs were observed. Further, higher baseline aortic stiffness was associated with poor semantic fluency (B = -0.47, 95% CI -0.76 to -0.18, Bonferroni-corrected p < 0.007) and verbal learning outcomes (B = -0.36, 95% CI -0.60 to -0.12, Bonferroni-corrected p < 0.007). As with all observational studies, it was not possible to infer causal associations. The generalisability of the findings may be limited by the gender imbalance, high educational attainment, survival bias, and lack of ethnic and socioeconomic diversity in this cohort.\nOur findings indicate that faster rates of aortic stiffening in mid-to-late life were associated with poor brain WM microstructural integrity and reduced cerebral perfusion, likely due to increased transmission of pulsatile energy to the delicate cerebral microvasculature. Strategies to prevent arterial stiffening prior to this point may be required to offer cognitive benefit in older age.\nClinicalTrials.gov NCT03335696.', 'mimetype': 'text/plain', 'lang': 'en'}]
container {'state': 'active', 'ident': 'iznnn644szdwva7khyxqzc73bi', 'revision': '63650c44-20e1-4ac3-96b6-644df8de27d3', 'redirect': None, 'extra': {'abbrev': 'PLoS Med.', 'country': 'us', 'default_license': 'CC-BY', 'doaj': {'archive': ['LOCKSS', 'PMC/Europe PMC/PMC Canada'], 'as_of': '2020-10-08', 'crawl_permission': True, 'default_license': 'CC-BY', 'seal': True}, 'issne': '1549-1676', 'issnp': '1549-1277', 'kbart': {'lockss': {'year_spans': [[2004, 2009]]}}, 'languages': ['en'], 'publisher_type': 'oa', 'road': {'as_of': '2018-01-24'}, 'sherpa_romeo': {'color': 'green'}, 'urls': ['https://journals.plos.org/plosmedicine/', 'http://www.plosmedicine.org/']}, 'edit_extra': None, 'name': 'PLoS Medicine', 'container_type': 'journal', 'publisher': 'Public Library of Science', 'issnl': '1549-1277', 'wikidata_qid': 'Q1686921'}
container_id iznnn644szdwva7khyxqzc73bi
contribs [{'index': 0, 'creator_id': '2jop4wjkkfh6tfysxhc3il3qwe', 'creator': None, 'raw_name': 'Sana Suri', 'given_name': 'Sana', 'surname': 'Suri', 'role': 'author', 'raw_affiliation': 'Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, United Kingdom.', 'extra': {'more_affiliations': ['Oxford Centre for Human Brain Activity, Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, United Kingdom.'], 'orcid': '0000-0002-5136-8302'}}, {'index': 1, 'creator_id': 'j47ct2rg6nddhjak5e3tot6u6q', 'creator': None, 'raw_name': 'Scott T Chiesa', 'given_name': 'Scott T', 'surname': 'Chiesa', 'role': 'author', 'raw_affiliation': 'Institute of Cardiovascular Science, University College London, London, United Kingdom.', 'extra': {'orcid': '0000-0003-4323-2189'}}, {'index': 2, 'creator_id': '4dzmpzlkyjawto6znjbostwnem', 'creator': None, 'raw_name': 'Enikő Zsoldos', 'given_name': 'Enikő', 'surname': 'Zsoldos', 'role': 'author', 'raw_affiliation': 'Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, United Kingdom.', 'extra': {'more_affiliations': ['Oxford Centre for Human Brain Activity, Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, United Kingdom.'], 'orcid': '0000-0002-0478-6165'}}, {'index': 3, 'creator_id': '2vetkwvapva6npr55zpcfhtsbm', 'creator': None, 'raw_name': 'Clare E Mackay', 'given_name': 'Clare E', 'surname': 'Mackay', 'role': 'author', 'raw_affiliation': 'Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, United Kingdom.', 'extra': {'more_affiliations': ['Oxford Centre for Human Brain Activity, Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, United Kingdom.'], 'orcid': '0000-0001-6111-8318'}}, {'index': 4, 'creator_id': 'y23qyudf75hxdha5tuh7z5rbya', 'creator': None, 'raw_name': 'Nicola Filippini', 'given_name': 'Nicola', 'surname': 'Filippini', 'role': 'author', 'raw_affiliation': 'Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, United Kingdom.', 'extra': {'more_affiliations': ['Oxford Centre for Human Brain Activity, Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, United Kingdom.'], 'orcid': '0000-0003-1513-5269'}}, {'index': 5, 'creator_id': 'xz5q4i2iszdz5pnsq3yzoxif3q', 'creator': None, 'raw_name': 'Ludovica Griffanti', 'given_name': 'Ludovica', 'surname': 'Griffanti', 'role': 'author', 'raw_affiliation': 'Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, United Kingdom.', 'extra': {'more_affiliations': ['Oxford Centre for Human Brain Activity, Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, United Kingdom.'], 'orcid': '0000-0002-0540-9353'}}, {'index': 6, 'creator_id': '3bxwq6o2vrhyxa7y4vjnggkdfa', 'creator': None, 'raw_name': 'Abda Mahmood', 'given_name': 'Abda', 'surname': 'Mahmood', 'role': 'author', 'raw_affiliation': 'Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, United Kingdom.', 'extra': {'orcid': '0000-0002-3267-4590'}}, {'index': 7, 'creator_id': '3grjobflcjcbdc3uquykpqesie', 'creator': None, 'raw_name': 'Archana Singh-Manoux', 'given_name': 'Archana', 'surname': 'Singh-Manoux', 'role': 'author', 'raw_affiliation': 'Department of Epidemiology and Public Health, University College London, London, United Kingdom.', 'extra': {'more_affiliations': ['Inserm U1153, Epidemiology of Ageing and Neurodegenerative diseases, Université de Paris, Paris, France.'], 'orcid': '0000-0002-1244-5037'}}, {'index': 8, 'creator_id': None, 'creator': None, 'raw_name': 'Martin J Shipley', 'given_name': 'Martin J', 'surname': 'Shipley', 'role': 'author', 'raw_affiliation': 'Department of Epidemiology and Public Health, University College London, London, United Kingdom.', 'extra': {}}, {'index': 9, 'creator_id': 't6wwt62oifdd5oleixyx3vtgkq', 'creator': None, 'raw_name': 'Eric J Brunner', 'given_name': 'Eric J', 'surname': 'Brunner', 'role': 'author', 'raw_affiliation': 'Department of Epidemiology and Public Health, University College London, London, United Kingdom.', 'extra': {'orcid': '0000-0002-0595-4474'}}, {'index': 10, 'creator_id': 'mnke6iyccff3tg5qqbacw7mlme', 'creator': None, 'raw_name': 'Mika Kivimäki', 'given_name': 'Mika', 'surname': 'Kivimäki', 'role': 'author', 'raw_affiliation': 'Department of Epidemiology and Public Health, University College London, London, United Kingdom.', 'extra': {'orcid': '0000-0002-4699-5627'}}, {'index': 11, 'creator_id': None, 'creator': None, 'raw_name': 'John E Deanfield', 'given_name': 'John E', 'surname': 'Deanfield', 'role': 'author', 'raw_affiliation': 'Institute of Cardiovascular Science, University College London, London, United Kingdom.', 'extra': {}}, {'index': 12, 'creator_id': 'agyogcuwirhrlbohyxnsm32o5q', 'creator': None, 'raw_name': 'Klaus P Ebmeier', 'given_name': 'Klaus P', 'surname': 'Ebmeier', 'role': 'author', 'raw_affiliation': 'Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, United Kingdom.', 'extra': {'orcid': '0000-0002-5190-7038'}}]
edit_extra
ext_ids {'doi': '10.1371/journal.pmed.1003467', 'wikidata_qid': None, 'isbn13': None, 'pmid': '33373359', 'pmcid': 'PMC7771705', 'core': None, 'arxiv': None, 'jstor': None, 'ark': None, 'mag': None, 'doaj': None, 'dblp': None, 'oai': None}
files [{'state': 'active', 'ident': 'umw5ykl5qjg6pffjogurg6wqyq', 'revision': '285ec6aa-5035-48e8-9fac-8b36cc564fcb', 'redirect': None, 'extra': None, 'edit_extra': None, 'size': 1697967, 'md5': '1e43d85ddfcacaa5afd58ffa65ccff3f', 'sha1': '04fb3402da3c4ca72f7099a8d7d8be7974f88836', 'sha256': '8b89ac1316ba431969dd7b973049d8aa924ea5033b612706b24409d18d1293de', 'urls': [{'url': 'https://web.archive.org/web/20210105194222/https://storage.googleapis.com/plos-corpus-prod/10.1371/journal.pmed.1003467/1/pmed.1003467.pdf?X-Goog-Algorithm=GOOG4-RSA-SHA256&X-Goog-Credential=wombat-sa%40plos-prod.iam.gserviceaccount.com%2F20210105%2Fauto%2Fstorage%2Fgoog4_request&X-Goog-Date=20210105T194222Z&X-Goog-Expires=3600&X-Goog-SignedHeaders=host&X-Goog-Signature=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', 'rel': 'webarchive'}, {'url': 'https://storage.googleapis.com/plos-corpus-prod/10.1371/journal.pmed.1003467/1/pmed.1003467.pdf?X-Goog-Algorithm=GOOG4-RSA-SHA256&X-Goog-Credential=wombat-sa%40plos-prod.iam.gserviceaccount.com%2F20210105%2Fauto%2Fstorage%2Fgoog4_request&X-Goog-Date=20210105T194222Z&X-Goog-Expires=3600&X-Goog-SignedHeaders=host&X-Goog-Signature=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', 'rel': 'publisher'}], 'mimetype': 'application/pdf', 'release_ids': ['vnf4556zcjfqfmtdnfzzuw5wzm'], 'releases': None}]
filesets []
ident vnf4556zcjfqfmtdnfzzuw5wzm
issue 12
language en
license_slug
number
original_title
pages e1003467
publisher
redirect
refs [{'index': 0, 'target_release_id': 'lhs25kbmo5h2pn4lpjegkskzoa', 'extra': {'pmid': '15972613', 'unstructured': 'J Gerontol A Biol Sci Med Sci. 2005 May;60(5):607-12'}, 'key': None, 'year': None, 'container_name': None, 'title': None, 'locator': None}, {'index': 1, 'target_release_id': 'ivqx37cdszg2tdul2qhkiyjf5y', 'extra': {'pmid': '31776832', 'unstructured': 'Eur J Epidemiol. 2020 Sep;35(9):861-869'}, 'key': None, 'year': None, 'container_name': None, 'title': None, 'locator': None}, {'index': 2, 'target_release_id': 'ozbuzdl435buja3hied35gj5sm', 'extra': {'pmid': '27327500', 'unstructured': 'Nat Commun. 2016 Jun 21;7:11934'}, 'key': None, 'year': None, 'container_name': None, 'title': None, 'locator': None}, {'index': 3, 'target_release_id': 'q2i2ip2se5bgneihcxwfblipei', 'extra': {'pmid': '28222517', 'unstructured': 'J Alzheimers Dis. 2017;57(1):195-204'}, 'key': None, 'year': None, 'container_name': None, 'title': None, 'locator': None}, {'index': 4, 'target_release_id': 'nvj4kspoibhlvn56dboa2idary', 'extra': {'pmid': '22075523', 'unstructured': 'Brain. 2011 Nov;134(Pt 11):3398-407'}, 'key': None, 'year': None, 'container_name': None, 'title': None, 'locator': None}, {'index': 5, 'target_release_id': 'lewhmlbygfcc5kyzpglpmpc75y', 'extra': {'pmid': '31063866', 'unstructured': 'Ageing Res Rev. 2019 Aug;53:100907'}, 'key': None, 'year': None, 'container_name': None, 'title': None, 'locator': None}, {'index': 6, 'target_release_id': 'tdnwbogombct7i5gnnhempg7o4', 'extra': {'pmid': '32738937', 'unstructured': 'Lancet. 2020 Aug 8;396(10248):413-446'}, 'key': None, 'year': None, 'container_name': None, 'title': None, 'locator': None}, {'index': 7, 'target_release_id': 'bi7exkmskzc2zfjjnvtjtiirha', 'extra': {'pmid': '28991365', 'unstructured': 'J Neurochem. 2018 Mar;144(5):527-548'}, 'key': None, 'year': None, 'container_name': None, 'title': None, 'locator': None}, {'index': 8, 'target_release_id': 'd52wto5pqrcznlekwhdfhqyecy', 'extra': {'pmid': '28315460', 'unstructured': 'Neuroimage. 2018 Apr 15;170:174-181'}, 'key': None, 'year': None, 'container_name': None, 'title': None, 'locator': None}, {'index': 9, 'target_release_id': 'yrhdrjlibnafvexmrerhq6tmrq', 'extra': {'pmid': '26791155', 'unstructured': 'Neurology. 2016 Feb 16;86(7):619-26'}, 'key': None, 'year': None, 'container_name': None, 'title': None, 'locator': None}, {'index': 10, 'target_release_id': 'n2v5b5gdfbc5bdwgs5fmf7yztq', 'extra': {'pmid': '16151027', 'unstructured': 'Stroke. 2005 Oct;36(10):2193-7'}, 'key': None, 'year': None, 'container_name': None, 'title': None, 'locator': None}, {'index': 11, 'target_release_id': 'cngyrpkq4jdjjduikrt7uflgw4', 'extra': {'pmid': '17698497', 'unstructured': 'Brain. 2007 Sep;130(Pt 9):2375-86'}, 'key': None, 'year': None, 'container_name': None, 'title': None, 'locator': None}, {'index': 12, 'target_release_id': 'q5c7jbnhgba23cvz5niqcgh7iy', 'extra': {'pmid': '30018169', 'unstructured': 'Circulation. 2018 Oct 30;138(18):1951-1962'}, 'key': None, 'year': None, 'container_name': None, 'title': None, 'locator': None}, {'index': 13, 'target_release_id': '4um77ocud5f5vmhrrpuug7q72y', 'extra': {'pmid': '24132374', 'unstructured': 'Neurology. 2013 Nov 5;81(19):1711-8'}, 'key': None, 'year': None, 'container_name': None, 'title': None, 'locator': None}, {'index': 14, 'target_release_id': 'vwb34udamzalbm6ayylfdemt5a', 'extra': {'pmid': '10404910', 'unstructured': 'JAMA. 1999 Jul 7;282(1):40-6'}, 'key': None, 'year': None, 'container_name': None, 'title': None, 'locator': None}, {'index': 15, 'target_release_id': 'di4pq3qdmbd5fflqldypfsovv4', 'extra': {'pmid': '19237680', 'unstructured': 'Hypertension. 2009 Apr;53(4):668-73'}, 'key': None, 'year': None, 'container_name': None, 'title': None, 'locator': None}, {'index': 16, 'target_release_id': 'ayjv6d3igvfixem7m7rx263ibu', 'extra': {'pmid': '24548924', 'unstructured': 'Ageing Res Rev. 2014 May;15:16-27'}, 'key': None, 'year': None, 'container_name': None, 'title': None, 'locator': None}, {'index': 17, 'target_release_id': None, 'extra': {'pmid': '30448213', 'unstructured': 'Neuroimage. 2019 Feb 1;186:577-585'}, 'key': None, 'year': None, 'container_name': None, 'title': None, 'locator': None}, {'index': 18, 'target_release_id': 'ey6qswgtmnfxrndaqhrpr2plje', 'extra': {'pmid': '26965846', 'unstructured': 'Stroke. 2016 Apr;47(4):1030-6'}, 'key': None, 'year': None, 'container_name': None, 'title': None, 'locator': None}, {'index': 19, 'target_release_id': '2yebodicarhdrd3lz22insha3e', 'extra': {'pmid': '15576467', 'unstructured': 'Int J Epidemiol. 2005 Apr;34(2):251-6'}, 'key': None, 'year': None, 'container_name': None, 'title': None, 'locator': None}, {'index': 20, 'target_release_id': 'rqqlytmhfzdn3aumm2llhaepfy', 'extra': {'pmid': '24885374', 'unstructured': 'BMC Psychiatry. 2014 May 30;14:159'}, 'key': None, 'year': None, 'container_name': None, 'title': None, 'locator': None}, {'index': 21, 'target_release_id': 'ajfu7hz5tzg6hbjt3rzbexw7f4', 'extra': {'pmid': '18501637', 'unstructured': 'Neuroimage. 2009 Jan 1;44(1):83-98'}, 'key': None, 'year': None, 'container_name': None, 'title': None, 'locator': None}, {'index': 22, 'target_release_id': '7rqeh2qvp5bkbg4grkjxsalizi', 'extra': {'pmid': '23637918', 'unstructured': 'PLoS One. 2013 Apr 30;8(4):e61855'}, 'key': None, 'year': None, 'container_name': None, 'title': None, 'locator': None}, {'index': 23, 'target_release_id': 'twhcuhuxwvcohcxwpgzvx4hsyu', 'extra': {'pmid': '26505140', 'unstructured': 'J Psychiatry Neurosci. 2016 Apr;41(3):162-8'}, 'key': None, 'year': None, 'container_name': None, 'title': None, 'locator': None}, {'index': 24, 'target_release_id': '37c2aeh5xjg4dkny7pd47q6nqa', 'extra': {'pmid': '24530839', 'unstructured': 'Neuroimage. 2014 May 15;92:381-97'}, 'key': None, 'year': None, 'container_name': None, 'title': None, 'locator': None}, {'index': 25, 'target_release_id': 'b3v34nu7lnhflatw4om27syose', 'extra': {'pmid': '21444833', 'unstructured': 'Hypertension. 2011 May;57(5):1003-9'}, 'key': None, 'year': None, 'container_name': None, 'title': None, 'locator': None}, {'index': 26, 'target_release_id': 'rgfgzijljrdrhctltyyr4h7zte', 'extra': {'pmid': '25623500', 'unstructured': 'Neuroimage. 2015 Apr 15;110:162-70'}, 'key': None, 'year': None, 'container_name': None, 'title': None, 'locator': None}, {'index': 27, 'target_release_id': '6tqfoa3c3bhajprqlhqpolj65e', 'extra': {'pmid': '26056335', 'unstructured': 'Hypertension. 2015 Aug;66(2):294-300'}, 'key': None, 'year': None, 'container_name': None, 'title': None, 'locator': None}, {'index': 28, 'target_release_id': 'bkrshe3eejcxpc4rdkx6tvohme', 'extra': {'pmid': '18360021', 'unstructured': 'Hypertens Res. 2008 Jan;31(1):75-81'}, 'key': None, 'year': None, 'container_name': None, 'title': None, 'locator': None}, {'index': 29, 'target_release_id': 'jsudoaoehndcrasgbtk75z5s3m', 'extra': {'pmid': '31225888', 'unstructured': 'JAMA Netw Open. 2019 Jun 5;2(6):e195776'}, 'key': None, 'year': None, 'container_name': None, 'title': None, 'locator': None}, {'index': 30, 'target_release_id': 'jskorh5zpbdtlcyyvmcvtf6gr4', 'extra': {'pmid': '18852384', 'unstructured': 'Hypertension. 2008 Dec;52(6):1120-6'}, 'key': None, 'year': None, 'container_name': None, 'title': None, 'locator': None}, {'index': 31, 'target_release_id': 'uzh6g5uiabgxflsirdpr72z4zy', 'extra': {'pmid': '26754644', 'unstructured': 'Hypertension. 2016 Mar;67(3):513-9'}, 'key': None, 'year': None, 'container_name': None, 'title': None, 'locator': None}, {'index': 32, 'target_release_id': '62c4phwuhjbsnpb2jo5lsylwfi', 'extra': {'pmid': '16624579', 'unstructured': 'Neuroimage. 2006 Jul 15;31(4):1487-505'}, 'key': None, 'year': None, 'container_name': None, 'title': None, 'locator': None}, {'index': 33, 'target_release_id': 'irbn74embjghblwec46qhi6gxa', 'extra': {'pmid': '17272780', 'unstructured': 'Stroke. 2007 Mar;38(3):888-92'}, 'key': None, 'year': None, 'container_name': None, 'title': None, 'locator': None}, {'index': 34, 'target_release_id': None, 'extra': {'pmid': '30571552', 'unstructured': 'Hypertension. 2019 Jan;73(1):217-228'}, 'key': None, 'year': None, 'container_name': None, 'title': None, 'locator': None}, {'index': 35, 'target_release_id': 'nh66k3klurgdfo4tiigem6aloa', 'extra': {'pmid': '18259005', 'unstructured': 'Hypertension. 2008 Apr;51(4):1123-8'}, 'key': None, 'year': None, 'container_name': None, 'title': None, 'locator': None}, {'index': 36, 'target_release_id': '6if47egjsjekvdjqjfocagsaa4', 'extra': {'pmid': '15817019', 'unstructured': 'J Am Geriatr Soc. 2005 Apr;53(4):695-9'}, 'key': None, 'year': None, 'container_name': None, 'title': None, 'locator': None}, {'index': 37, 'target_release_id': '672345j4nzgdjmhxzmqklhlt2m', 'extra': {'pmid': '20083680', 'unstructured': 'Circulation. 2010 Feb 2;121(4):505-11'}, 'key': None, 'year': None, 'container_name': None, 'title': None, 'locator': None}, {'index': 38, 'target_release_id': 'r5hjibl2vbgb7f3wdwvm5c4rlq', 'extra': {'pmid': '25030502', 'unstructured': 'Curr Neurol Neurosci Rep. 2014 Sep;14(9):475'}, 'key': None, 'year': None, 'container_name': None, 'title': None, 'locator': None}, {'index': 39, 'target_release_id': 'u3q4wx3l2rhetg2oufol7btgqi', 'extra': {'pmid': '18025297', 'unstructured': 'Hypertension. 2008 Jan;51(1):99-104'}, 'key': None, 'year': None, 'container_name': None, 'title': None, 'locator': None}]
release_date 2020-12-29
release_stage published
release_type article-journal
release_year 2020
revision d72c1892-63c6-425b-9450-cd33fb8574ef
state active
subtitle
title Associations between arterial stiffening and brain structure, perfusion, and cognition in the Whitehall II Imaging Sub-study: A retrospective cohort study
version
volume 17
webcaptures []
withdrawn_date
withdrawn_status
withdrawn_year
work_id nwo3qp57ejephnp6kprpbcgs7m
As JSON via API

Extra Metadata (raw JSON)

pubmed.pub_types ['Journal Article']