Sabas Carlos Vieira-Rua Félix Pacheco, 2.159, sala 305-CEP: 64001-160-Teresina (PI) release_uyboxyhtyra4bnvkmck65zyuom

by Sabas Vieira, Juliana Ribeiro, Nayara Gomes Almeida, Carla Keliany, Duarte De Araújo, Amanda Eugênia, Almeida Rocha, Willamis Ferreira, Melo Júnior, Lina Santos, Benedita Leal De Abreu, Adriana De (+1 others)

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Abstract

Keywords Breast neoplasms Sentinel Lymph Node Biopsy Lymphoscintigraphy Frozen sections False negative reactions Descritores Neoplasias da mama Biópsia de linfonodo sentinela Linfocintigrafia Secções congeladas Reações falso-negativas RESUMO Objetivo: Avaliar a taxa de falso-negativo do exame de congelação do linfonodo sentinela em câncer de mama e os fatores associados à mesma. Método: Duzentos e noventa e nove pacien-tes com câncer de mama que se submeteram à linfocintilografia com uso de tecnécio-99m e biópsia de linfonodo sentinela (LS) entre Março/2005 e Fevereiro/2009 foram avaliadas em relação às seguintes variáveis: idade, tamanho do tumor, padrão de drenagem linfática à linfocintilografia, características histológicas do tumor (tipo e grau de diferenciação) e diag-nóstico do exame de congelação e histopatológico definitivo do LS. Resultados: A taxa de falso-negativo no exame de congelação do LS foi 4,3% (10 casos). A especificidade foi 100%; a sensibilidade, 87,2%; o valor preditivo positivo, 100% e o valor preditivo negativo foi 95,7%. Nenhuma das variáveis avaliadas esteve associada a aumento na incidência de falso-negativo. Houve associação entre tamanho do tumor e incidência de metástase axilar (p=0,00008). Conclusões: A taxa de falso-negativo do exame de congelação do LS foi 4,3% e nenhuma das variáveis avaliadas se correlacionou com esse evento. ABSTRACT Objective: Evaluate the rate of false-negative sentinel node frozen section on breast cancer and its influencing factors. Method: two hundred and ninety nine patients with breast cancer that underwent lymphoscintigraphy with technetium-99m followed by sentinel node biopsy between March/2005 and February/2009 were evaluated in relation to the following factors: age, tumor size, lymphatic drainage pattern in the lymphoscintigraphy, tumor histologic features (differentiation, type and degree), frozen section diagnosis, and permanent section diagnosis. Results: The false negative rate in the sentinel node frozen section was 4. 3% (10 patients). The specificity was 100%, the sensitivity was 87.2%, positive predictive value was 100% and the negative predictive value was 95.7%. None of the variables evaluated were associated with a raise in the false-negative incidence. There was an association between the tumor size and the incidence of axillary metastasis (p=0,00008). Conclusion: The false-negative rate of the sentinel node frozen section was 4.3% and none of the evaluated variables was associated with this event.
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