EFFECT OF RANDIA DUMETORUM LAM ON CLONIDINE AND HALOPERIDOL-INDUCED CATALEPSY IN MICE release_ugr7f6xlrnaplfopt7k6dzzxyy

by M Ghaisas, P Ninave, G Ganu, V Zope, M Tanwar, A Deshpande, Mr Mahesh, M Ghaisas Head

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Abstract

In the present study we evaluated the anticataleptic efficacy of ethanolic extract of Randia dumetorum fruits in clonidine and haloperidol-induced catalepsy in mice. Five groups (n=5) of albino mice were used in the study. Catalepsy was induced by clonidine (1 mg/kg, s.c.) and haloperidol (1 mg/kg, i.p) in clonidine and haloperidol-induced catalepsy in mice respectively. The degree of catalepsy (cataleptic score) was measured as the time the animal maintained an imposed posture. In the clonidine-induced catalepsy model significant (p<0.01) reduction in the cataleptic scores was observed in all the groups treated with Randia dumetorum Lam (180, 360, 720 mg/kg, p.o.) however there was no significant reduction in the cataleptic scores in the haloperidol-induced catalepsy model in mice. The results obtained in the present study indicate that the anticataleptic activity exhibited by ethanolic extract of Randia dumetorum Lam fruits can be attributed to the antihistaminic activity; however Randia dumetorum does not possess antidopaminergic and antiserotonergic activity.
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