Mycoplasma Infection Mediates Sensitivity of Multidrug-Resistant Cell Lines to Tiopronin: A Cautionary Tale release_ub5bgrbferev5lucfebzjtrgme

by Lyn M. Huff, Sachi Horibata, Robert W. Robey, Matthew D. Hall, Michael M. Gottesman

Published in Journal of Medicinal Chemistry by American Chemical Society (ACS).

2019   Volume 63, Issue 3, p1434-1439

Abstract

We previously reported that some, but not all, multidrug-resistant cells that overexpressed various drug-resistance transporters were collaterally sensitive to tiopronin. In recent follow-up studies, we discovered that sensitivity to tiopronin in the original study was mediated by infection of the cells by a human-specific strain of mycoplasma. These results strongly support the need to constantly monitor cells for mycoplasma infection and keep stored samples of all cells that are used for in vitro studies.
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Type  article-journal
Stage   published
Date   2019-11-08
Language   en ?
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ISSN-L:  0022-2623
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