Noncoding RNAs in Acute Myeloid Leukemia: From Key Regulators to Clinical Players release_tqry6ss2iffuhb2n7pj6ufj6su

by Alessandro Fatica

Published in Scientifica by Hindawi Limited.

2012   Volume 2012, p1-10


Recent analyses have shown that human cells transcribe almost their entire genomes, implying the existence of a huge mass of ncRNAs. At the present, microRNAs are the most investigated regulative non-coding RNAs. Several studies have demonstrated that microRNAs play a crucial role in hematopoietic differentiation and hematological malignancies, including acute myeloid leukemia (AML). Aberrant expression of microRNAs has been associated with specific genetic abnormalities and clinical outcome of patients with AML. In addition, since microRNAs can function as either oncogenes or tumor suppressor genes, the potential of using these molecules as therapeutic targets opens up new opportunities in the future of AML therapy. The recent demonstration that other regulatory ncRNAs, in addition to microRNAs, are involved in hematopoietic cell differentiation and diseases, suggests that they may also have a biological relevance in AML. This paper will describe the role of ncRNAs in AML and discuss the expectations for the use of ncRNAs in diagnosis, prognosis, and therapy of AML.
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Type  article-journal
Stage   published
Year   2012
Language   en ?
DOI  10.6064/2012/925758
PubMed  24278756
PMC  PMC3820507
Wikidata  Q38166375
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ISSN-L:  2090-908X
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