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iTALK: an R Package to Characterize and Illustrate Intercellular Communication
release_tgarmdfar5bcroyw3uw3yelkjq
by
Yuanxin Wang, Ruiping Wang, Shaojun Zhang, Shumei Song, Changying Jiang, Guangchun Han, Michael Wang, Jaffer Ajani, Andy Futreal, Linghua Wang
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by Cold Spring Harbor Laboratory.
2019
Abstract
Crosstalk between tumor cells and other cells within the tumor microenvironment (TME) plays a crucial role in tumor progression, metastases, and therapy resistance. We present iTALK, a computational approach to characterize and illustrate intercellular communication signals in the multicellular tumor ecosystem using single-cell RNA sequencing data. iTALK can in principle be used to dissect the complexity, diversity, and dynamics of cell-cell communication from a wide range of cellular processes.
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Date 2019-01-04
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Date 2019-01-04
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10.1101/507871
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