Computational approaches to analysis of DNA microarray data release_sx6nzpjtezbollzb34up5fnmoi

by J Quackenbush

Published in IMIA Yearbook of Medical Informatics.

2006   p91-103

Abstract

To review the current state of the art in computational methods for the analysis of DNA microarray data. The review considers methods of microarray data collection, transformation and representation, comparisons and predictions of gene expression from the data, their mechanistic analysis, related systems biology, and the application of clustering techniques. Functional genomics approaches have greatly increased the rate at which data on biological systems is generated, leading to corresponding challenges in analyzing the data through advanced computational techniques. The paper compares and contrasts the application of computational clustering for discovery, comparison, and prediction of gene expression classes, together with their evaluation and relation to mechanistic analyses of biological systems. Methods for assaying gene expression levels by DNA microarray experiments produce considerably more data than other techniques, and require a wide variety of computational techniques for identifying patterns of expression that may be biologically significant. These will have to be verified and validated by comparison to results from other methods, integrated with other systems data, and provide the feedback for further experimentation for testing mechanistic or other biological hypotheses.
In text/plain format

Archived Files and Locations

application/pdf  94.5 kB
file_o2ea3zlyunfrzgrovg3iiuzlnm
dp.univr.it (web)
web.archive.org (webarchive)
Read Archived PDF
Preserved and Accessible
Type  article-journal
Stage   published
Year   2006
Language   en ?
PubMed  17051302
Container Metadata
Not in DOAJ
In Keepers Registry
ISSN-L:  0943-4747
Work Entity
access all versions, variants, and formats of this works (eg, pre-prints)
Catalog Record
Revision: 08001c5d-fa28-4ae6-9e36-021b7e6013e8
API URL: JSON