{"DOI":"10.6084/m9.figshare.3545435","abstract":"The objective of this study was to examine the in vitro combinatorial anticancer effects of curcumin and sorafenib towards thyroid cancer cells FTC133 using a MTT cytotoxicity assay, and to test whether the mechanism involves induction of apoptosis. The present results demonstrated that curcumin at 15\u201325 \u03bcM dose-dependently suppressed the proliferation of FTC133. Combined treatment (curcumin (25 \u03bcM) and sorafenib (2 \u03bcM)) resulted in a reduction in cell colony formation and significantly decreased the invasion and migration of FTC133 cells compared with that treated with individual drugs. Western blot showed that the levels of p-ERK and p-Akt proteins were significantly reduced (p","author":[{"family":"Zhang"},{"family":"Yu"},{"family":"Xie","given":"Rong"},{"family":"Chen"},{"family":"Lv"}],"id":"unknown","issued":{"date-parts":[[2016,8,7]]},"publisher":"Figshare","title":"Combinatorial anticancer effects of curcumin and sorafenib towards thyroid cancer cells via PI3K/Akt and ERK pathways","type":"article-journal"}