abstracts[] |
{'sha1': 'a6834b75c272a4d95fb62cbdc67dee56474d83f8', 'content': 'Multidrug-resistant Acinetobacter baumannii are increasingly becoming problematic to the healthcare system globally due to limited effective antibiotics. This thesis investigated the potential of repositioning non-antibiotic drugs for use in combination with polymyxin B to enhance the bacterial killing of this last-line antibiotic against these pathogens and prevent the emergence of polymyxin resistance. The in vitro and in vivo studies identified numerous promising non-antibiotic candidates with synergistic antimicrobial activity against multiple Gram-negative bacteria including A. baumannii. The metabolomic studies revealed potential bacterial killing mechanisms of a novel combination and transcriptomic studies discovered numerous potential targets for future repositioning of non-antibiotic drugs.', 'mimetype': 'text/plain', 'lang': 'en'}
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contribs[] |
{'index': 0, 'creator_id': None, 'creator': None, 'raw_name': 'THIEN BON TRAN', 'given_name': None, 'surname': None, 'role': 'author', 'raw_affiliation': None, 'extra': None}
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ext_ids |
{'doi': '10.4225/03/5aca9a0b220ac', 'wikidata_qid': None, 'isbn13': None, 'pmid': None, 'pmcid': None, 'core': None, 'arxiv': None, 'jstor': None, 'ark': None, 'mag': None, 'doaj': None, 'dblp': None, 'oai': None, 'hdl': None}
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RS-INC
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publisher |
Monash University
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[]
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release_date |
2018-04-03
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release_stage |
published
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release_type |
article-journal
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release_year |
2018
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subtitle |
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title |
Treatment of multidrug-resistant Acinetobacter baumannii with novel combinations of polymyxin B and other non-antibiotic drugs
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imnpz62rdfcetmgm6pkf6d7xya
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