Circulating Metabolites and Lipids are Associated to Diabetic Retinopathy in Individuals With Type 1 Diabetes release_rev_93a4ea60-332f-44b6-9fb9-0fc6321fd2d8

by Viktor Rotbain Curovic, Tommi Suvitaival, Ismo Mattila, Linda Ahonen, Kajetan Trošt, Simone Theilade, Tine W. Hansen, Cristina Legido-Quigley, Peter Rossing

Published in Diabetes by American Diabetes Association.

2020   db200104

Abstract

Omics based methods may provide new markers associated to diabetic retinopathy (DR). We investigated a wide omics panel of metabolites and lipids related to DR in type 1 diabetes. Metabolomic analyses were performed using two-dimensional gas chromatography with time-of-flight mass spectrometry and lipidomic analyses utilizing an ultra-high-performance liquid chromatography quadruple time-of-flight mass spectrometry method in 648 individuals with type 1 diabetes. Subjects were sub-divided into: no DR, mild non-proliferative DR (NPDR), moderate NPDR, severe NPDR and proliferative DR. Endpoints were any progression of DR, onset of DR and progression from mild to severe DR tracked from standard ambulatory care and investigated using Cox models. The cohort consisted of 648 participants aged mean 54.4±12.8 years, 55.5% were male, and follow-up was 5.1-5.5 years. Cross-sectionally, 2,4-dihydroxybutyric acid (DHBA), 3,4-DHBA, ribonic acid, ribitol, and the triglycerides 50:1 and 50:2 significantly correlated (p<0.042) to DR stage. Longitudinally, higher 3,4-DHBA was a risk marker for progression of DR (n=133) after adjustment (p=0.033). We demonstrated multiple metabolites being positively correlated to higher grade of DR in type 1 diabetes, and several triglycerides being negatively correlated. Furthermore, higher 3,4-DHBA was an independent risk marker for progression of DR, however, confirmation is required.
In text/plain format

Type  article-journal
Stage   published
Date   2020-07-31
Language   en ?
DOI  10.2337/db20-0104
PubMed  32737117
Container Metadata
Not in DOAJ
In Keepers Registry
ISSN-L:  0012-1797
Work Entity
access all versions, variants, and formats of this works (eg, pre-prints)
Revision

This is a specific, static metadata record, not necessarily linked to any current entity in the catalog.

Catalog Record
Revision: 93a4ea60-332f-44b6-9fb9-0fc6321fd2d8
API URL: JSON