Regular Exercise to Prevent the Recurrence of Gestational Diabetes Mellitus
A Randomized Controlled Trial release_qypycb7rdbhmfk7ykeuluczywa

by Kym J. Guelfi, Ming Jing Ong, Nicole A. Crisp, Paul A. Fournier, Karen E. Wallman, J. Robert Grove, Dorota A. Doherty, John P. Newnham

Published in Obstetrics and Gynecology by Ovid Technologies (Wolters Kluwer Health).

2016   Volume 128, Issue 4, p819-827

Abstract

To investigate the effect of a supervised home-based exercise program on the recurrence and severity of gestational diabetes mellitus (GDM) together with other aspects of maternal health and obstetric and neonatal outcomes. This randomized controlled trial allocated women with a history of GDM to an exercise intervention (14-week supervised home-based stationary cycling program) or to a control group (standard care) at 13±1 weeks of gestation. The primary outcome was a diagnosis of GDM. Secondary outcomes included maternal fitness, psychological well-being, and obstetric and neonatal outcomes. A sample size of 180 (90 in each group) was required to attain 80% power to detect a 40% reduction in the incidence of GDM. Between June 2011 and July 2014, 205 women provided written consent and completed baseline assessments. Of these, 33 (16%) were subsequently excluded as a result of an elevated baseline oral glucose tolerance test (OGTT), leaving 172 randomized to exercise (n=85) or control (n=87). Three women miscarried before the assessment of outcome measures (control=2; exercise=1). All remaining women completed the postintervention OGTT. The recurrence rate of GDM was similar between groups (control 40% [n=34]; exercise 40.5% [n=34]; P=.95) and the severity of GDM at diagnosis was unaffected by the exercise program with similar glucose and insulin responses to the OGTT (glucose 2 hours post-OGTT 7.7±1.5 compared with 7.6±1.6 mmol/L; P>.05). Maternal fitness was improved by the exercise program (P<.01) and psychological distress was reduced (P=.02). There were no differences in obstetric and neonatal outcomes between groups (P>.05). Supervised home-based exercise started at 14 weeks of gestation did not prevent the recurrence of GDM; however, it was associated with important benefits for maternal fitness and psychological well-being. ClinicalTrials.gov, https://clinicaltrials.gov, NCT01283854.
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Year   2016
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DOI  10.1097/aog.0000000000001632
PubMed  27607876
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