The prognostic and diagnostic markers of invasive candidiasis in patients during chemotherapy release_qqd7cillqbehrpdhi6rv6wmtly

by Agnieszka Magryś, Maria Kozioł-Montewka, Elzbieta Starosławska, Beata Gabczyńska

Published in Polish Journal of Microbiology.

2005   Volume 54, Issue 3, p207-13


The aim of the work was the early detection of Candida spp. in clinical samples of patients with carcinoma ovariorum undergoing chemotherapy by comparing three indicators of candidiasis: presence of mannan and yeast DNA in the bloodstream and colonization of mucosal membranes by Candida species as a prognostic marker of deep candidiasis. Thirty-one women with carcinoma ovariorum, during chemotherapy without symptoms of deep fungal infections, were examined twice over a six-day period. C. albicans was the dominant organism isolated from mucosal membranes. Two serum samples were positive for mannan on the first day of examination. All these patients were previously colonized by Candida spp. on mucous membranes. Four patients were positive on the last day of examination. Three of these patients were colonized by Candida spp. C. albicans infection was detected early in 4 out of 12 clinical samples by a combination of PCR and mannan-detecting methods. Colonization increases the risk of deep candidiasis. PCR and antigen detection are fast and reliable methods for early detection of Candida in bloodstream. For patients at risk, the clinical samples must be tested by at least two independent methods.
In text/plain format

Archived Files and Locations

application/pdf  218.0 kB
file_am7264x6knc7deryncbhfaq4my (web) (webarchive)
Read Archived PDF
Preserved and Accessible
Type  article-journal
Stage   published
Year   2005
Language   en ?
PubMed  16450836
Journal Metadata
Open Access Publication
In Keepers Registry
ISSN-L:  1733-1331
Work Entity
access all versions, variants, and formats of this works (eg, pre-prints)
Catalog Record
Revision: bd0df295-5860-4bcd-a111-f8699b0ee7b1