IS EXTRAEMBRYONIC ENDODERM A SOURCE OF PLACENTAL BLOOD CELLS?
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by
Karen M. Downs
Abstract
The extraembryonic hypoblast/visceral endoderm of Placentalia carries out a variety of functions during gestation, including hematopoietic induction. Results of decades-old and recent experiments have provided compelling evidence that, in addition to its inducing properties, hypoblast/visceral endoderm itself is a source of placental blood cells. Those observations which highlight extraembryonic endoderm's role as an overlooked source of placental blood cells across species are briefly discussed here, with suggestions for future exploration.
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