Statin Use and Influenza Vaccine Effectiveness in Persons >65 Years of Age, Taiwan release_q5sl3rayfjh2pcu6g7ncsfknjq

by Lung-Wen Tsai, Yung-Tai Chen, Chia-Jen Shih, Shuo-Ming Ou, Pei-Wen Chao, Shih-Hsiu Lo

Abstract

Debates on whether statin use reduces the effectiveness of influenza vaccines against critical illness and death among persons >65 years of age continue. We conducted a study of 9,427,392 persons >65 years of age who did and did not receive influenza vaccinations during 12 consecutive influenza seasons, 2000-01 through 2011-12. Using data from Taiwan's National Health Insurance Research Database, we performed propensity score-matching to compare vaccinated persons with unvaccinated controls. After propensity score-matching, the vaccinated group had lower risks for in-hospital death from influenza and pneumonia and for hospitalization for pneumonia and influenza, circulatory conditions, and critical illnesses compared with the unvaccinated group. We stratified the 2 groups by statin use and analyzed data by interaction analysis and saw no statistically significant difference. We found that influenza vaccine effectively reduced risks for hospitalization and death in persons >65 years of age, regardless of statin use.
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Published in Emerging Infectious Diseases by Centers for Disease Control and Prevention (CDC)
ISSN-L 1080-6040
Volume 29
Issue 6
Release Year 2020
Publisher Centers for Disease Control and Prevention (CDC)
Primary Language en (lookup)

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Year   2020
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ISSN-L:  1080-6040
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