The current study designed to investigate the effects of pre-treatment of aqueous extract of B. diffusa root (200-400 mg/kg/day) in repeated dose acetaminophen nephrotoxic rats for 14 days. Administration of acetaminophen to rats induced marked detritions of renal function, characterized by a significant increase in blood urea nitrogen (BUN), serum creatinine (p < 0.01) and injured the renal cells evident from increased level of kidney malondialdehyde (MDA), protein thiol (p < 0.01) along with depletion of super oxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) activities and reduced glutathione (GSH) levels (p < 0.01), however pre-treatment with B. diffusa extract protected against these changes. Histopathological changes showed that acetaminophen caused significant structural damages to kidneys like tubular necrosis, degeneration of epithelial cells, glomerular damage and congestion which was reversed with B. diffusa. The results suggest that B. diffusa has the potential in preventing the acetaminophen-induced nephrotoxicity.
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