Pseudomonas elastase acts as a virulence factor in burned hosts by Hageman factor-dependent activation of the host kinin cascade release_pkbqwlw77rdolehx6tcopasqe4

by I A Holder, A N Neely

Abstract

Purified Pseudomonas elastase injected subcutaneously into the skin of an Evans blue dye-injected (intravenously) guinea pig caused dye leakage similar to that observed when histamine or bradykinin was injected in the same animal. The histamine-induced dye leakage was ablated in antihistamine-treated guinea pigs, but elastase- and bradykinin-induced dye leakages were not. Local injections of specific inhibitors of the host Hageman factor-dependent bradykinin-generating pathway given immediately prior to elastase injection reduced dye leakage in a dose-related manner. Elastase-related dye release was enhanced when angiotension-converting enzyme inhibitor, a substance which prevents host enzymes from breaking down bradykinin, was injected prior to elastase injection. We conclude that Pseudomonas elastase generates bradykinin in the infected host via a Hageman factor-dependent pathway.
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Published in Infection and Immunity
ISSN-L 0019-9567
Volume 57
Issue 11
Page(s) 3345-8
Release Year 1989
Primary Language en (lookup)

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Type  article-journal
Stage   published
Year   1989
PubMed  2553607
PMC  PMC259817
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ISSN-L:  0019-9567
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