Hepatoprotective effects of Lactococcus chungangensis CAU 1447 in alcoholic liver disease release_pjtbqjecdfdb7g2kmomtskvelm

by YoHan Nam, Jong-Hwa Kim, Maytiya Konkit, Wonyong Kim

Published in Journal of Dairy Science by American Dairy Science Association.

2019   Volume 102, Issue 12, p10737-10747

Abstract

Alcoholic liver disease (ALD) is correlated with alcohol consumption, and ALD progression depends on various factors. Some lactic acid bacteria (LAB) are beneficial for mitigating ALD. However, the valuable effects of LAB-derived dairy products remain unclear. Here, we evaluated the effects of Lactococcus chungangensis CAU 1447 dry cells (CAU 1447) and cream cheese derived from CAU 1447 on ALD progression following long-term alcohol consumption in rats. Oral administration of CAU 1447 and CAU 1447 cream cheese significantly reduced alkaline phosphatase, aspartate aminotransferase, alanine aminotransferase, and triglyceride levels. We found that CAU 1447 and CAU 1447 cream cheese downregulated mRNA encoding various cytokines and antioxidative factors in the liver. Oral CAU 1447 cream cheese administration increased short-chain fatty acid, butyrate, and acetate levels in feces. Thus, administration of CAU 1447 and CAU 1447 cream cheese induced hepatoprotective effects, indicating potential applications as a supplement for ALD mitigation.
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Type  article-journal
Stage   published
Date   2019-09-11
Language   en ?
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ISSN-L:  0022-0302
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