Natural anti-A and Tn-cross-reactive IgM arise from developmental O-GalNAc glycosylations.* release_p555ir3rrzbwnlzw327tekozri

by Peter Arend

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abstracts[] {'sha1': 'd5fa9af419969bd9fde55068635a250f428a24d8', 'content': 'While eukaryotic <i>O</i>-GalNAc-Ser/Thr\nglycosylations do not occur in bacteria, the <i>O</i>-GalNAc glycan-bearing ovarian glycolipids, discovered in C57BL/10\nmice, are complementary to the syngeneic, anti-A-reactive immunoglobulin M\n(IgM), which does not appear in animals that have undergone ovariectomy prior\nto the onset of puberty. These murine ovarian glycolipids are also complementary to the <i>Helix pomatia</i> agglutinin, which has emerged\nfrom the protein coats of fertilized eggs of the snail and thus reveals the presence\nof functional snail <i>O</i>-GalNAc glycans.The\nhexameric structure of this lower eukaryotic, <i>Helix pomatia</i> agglutinin suggests evolutionary relationship to the mammalian\nnon-immune IgM molecule, which hypothetically obtains its complementarity from\nthe early trans-species <i>O</i>-GalNAc glycosylation of proteins and subsequent\nGalNAc transferase depletion that completes the cell differentiation processes\nand causes the release of <i>O</i>-glycan-depleted,\ncomplementary proteins, such as secretory IgM revealing the structure of the volatilely\nexpressed, "lost" glycan carrier through germline-specific serine residues.\nConsequently, the early or first <i>O</i>-GalNAc glycosylations of proteins\nappear metabolically related to those of the mucin-type, "aberrant" monosaccharide\nGalNAcĪ±1-<i>O</i>-Ser/Thr-R,\nalso referred to as the Tn antigen, and explain the anti-Tn cross-reactivity of\nanti-A-specific immunoglobulins and the pronounced occurrence of cross-reactive\nanti-Tn antibody in plasma from humans with histo (blood) group O. In fact, in\nhuman blood group O, A-allelic, phenotype-specific GalNAc glycosylation of\nplasma proteins does not occur, affecting the levels of the anti-Tn antibody,\nwhich may function as a growth regulator that, depending on its levels,\ninitiates a complex process of growth inhibition through enzyme-substrate\ncompetition with subsequent trans-species <i>O</i>-GalNAc-glycosylations.', 'mimetype': 'text/plain', 'lang': 'en'}
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release_date 2016-12-20
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release_type article-journal
release_year 2016
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title Natural anti-A and Tn-cross-reactive IgM arise from developmental O-GalNAc glycosylations.*
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datacite.resourceType Paper
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datacite.subjects [{'subject': 'Microbiology'}, {'subject': 'Hematology'}, {'subject': 'Medicine'}, {'subject': 'Biochemistry'}, {'subject': 'Developmental Biology'}, {'subject': 'Zoology'}, {'subject': 'Systems Biology'}, {'subject': 'Structural Biology'}, {'subject': 'Stem Cells'}, {'subject': 'Cell Biology'}, {'subject': 'Genetics'}]
release_month 12