Distribution of proteoglycans in the trabecular tissue of eyes with neovascular glaucoma release_p3vevg6srzfofkn2wefsovh254

by T Kubota, A Tawara, A Khalil, M Honda, H Inomata

Published in German journal of ophthalmology.

1996   Volume 5, Issue 6, p392-8

Abstract

We investigated histo-chemically the composition and distribution of proteoglycans in the trabecular tissue of eyes with neovascular glaucoma. Cupromeronic blue in combination with a series of enzyme digestions and nitrous acid treatment were used. The spaces between the trabecular beams were lined by a single layer of vascular endothelium and were filled with red blood cells. A basal lamina and microfibrils were detected just beneath the newly formed vascular endothelial cells. Chondroitin-sulfate- and dermatan-sulfate-type proteoglycans were present in association with collagen fibrils in the extracellular matrix. Heparan-sulfate-type proteoglycans were present in association with the basal lamina of both the vascular endothelial cells and the trabecular cells. It is unlikely that these abnormalities in the type or distribution of proteoglycans in the trabecular meshwork have a major role in the pathogenesis of glaucoma.
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Type  article-journal
Stage   published
Year   1996
Language   en ?
PubMed  9479524
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ISSN-L:  0941-2921
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