Comparison of microvascular endothelial function as measured by laser Doppler flowmeter among non-smoker and smoker males release_owixfroidbhxtga3ao5xjmdy7y

by Suresh Kumar Srinivasamurthy, Laxminarayana Kurady Bairy, Sareesh Narayanan Naduvil

Published in International Journal of Basic & Clinical Pharmacology by Medip Academy.

2023  

Abstract

Background: To understand the role of smoking in influencing endothelial function as assessed by LDF among non-smoker and smoker males. Methods: The LDF measurement for a total of 35 non-smokers and 16 smokers was done in the central research laboratory after written informed consent. The change in LDF signal in response to acetylcholine 100 µl, which was delivered to the forearm skin by iontophoresis, was measured as perfusion units (PU). Results: The pre-ACh LDF signal were statistically not significant between the groups. The increase in LDF signal was more prominent in non-smoker group. The LDF signal parameters such as differences in minimal response pre and post-ACh; difference in mean response pre and post ACh; the difference in maximal response pre and post ACh was not statistically significant between groups. However, the difference in the area under curve (AUC) pre and post-ACh (PU.min) (non-smoker 20089.34 (3438.92) vs smoker 13220.72 (3379.52); p=0.16) showed a trend towards statistical significance. Conclusions: Microvascular endothelial function as assessed by LDF signal among smokers (pack-years;1.9±1.44) and non-smokers is statistically insignificant. However, lower microvascular endothelial function is observed among smokers.
In application/xml+jats format

Archived Files and Locations

application/pdf  233.6 kB
file_2k3com2rxzdqhktgtwii76q54u
www.ijbcp.com (publisher)
web.archive.org (webarchive)
Read Archived PDF
Preserved and Accessible
Type  article-journal
Stage   published
Date   2023-02-09
Journal Metadata
Not in DOAJ
Not in Keepers Registry
ISSN-L:  2279-0780
Work Entity
access all versions, variants, and formats of this works (eg, pre-prints)
Catalog Record
Revision: 00f7f66e-6eed-49d8-a926-67add7a9b2e7
API URL: JSON