Beyond Poiseuille: Preservation Fluid Flow in an Experimental Model release_ovu4scljxnbeda5zgk6dcbmwsy

by Saurabh Singh, Lucy V. Randle, Paul T. Callaghan, Christopher J. E. Watson, Chris J. Callaghan

Published in Journal of Transplantation by Hindawi Limited.

2013   Volume 2013, p1-6

Abstract

Poiseuille's equation describes the relationship between fluid viscosity, pressure, tubing diameter, and flow, yet it is not known if cold organ perfusion systems follow this equation. We investigated these relationships in an<jats:italic>ex vivo</jats:italic>model and aimed to offer some rationale for equipment selection. Increasing the cannula size from 14 to 20 Fr increased flow rate by a mean (SD) of 13 (12)%. Marshall's hyperosmolar citrate was three times less viscous than UW solution, but flows were only 45% faster. Doubling the bag pressure led to a mean (SD) flow rate increase of only 19 (13)%, not twice the rate. When external pressure devices were used, 100 mmHg of continuous pressure increased flow by a mean (SD) of 43 (17)% when compared to the same pressure applied initially only. Poiseuille's equation was not followed; this is most likely due to "slipping" of preservation fluid within the plastic tubing. Cannula size made little difference over the ranges examined; flows are primarily determined by bag pressure and fluid viscosity. External infusor devices require continuous pressurisation to deliver high flow. Future studies examining the impact of perfusion variables on graft outcomes should include detailed equipment descriptions.
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Type  article-journal
Stage   published
Year   2013
Language   en ?
DOI  10.1155/2013/605326
PubMed  24062943
PMC  PMC3770057
Wikidata  Q39345448
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