Crystal structure of Nsp15 endoribonuclease NendoU from SARS-CoV-2 release_ofylcy3wn5eorbeqtpf56fav3u

by Youngchang Kim, Robert Jedrzejczak, Natalia I Maltseva, Mateusz Wilamowski, Michael Endres, Adam Godzik, Karolina Michalska, Andrzej Joachimiak

Published in Protein Science.

2020   Volume 29, Issue 7, p1596-1605

Abstract

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is rapidly spreading around the world. There is no existing vaccine or proven drug to prevent infections and stop virus proliferation. Although this virus is similar to human and animal SARS- and MERS-CoVs, the detailed information about SARS-CoV-2 proteins structures and functions is urgently needed to rapidly develop effective vaccines, antibodies and antivirals. We applied high-throughput protein production and structure determination pipeline at the Center for Structural Genomics of Infectious Diseases to produce SARS-CoV-2 proteins and structures. Here we report two high-resolution crystal structures of endoribonuclease Nsp15/NendoU. We compare these structures with previously reported homologs from SARS and MERS coronaviruses. This article is protected by copyright. All rights reserved.
In text/plain format

Archived Files and Locations

application/pdf  2.8 MB
file_h2kci3fwvfetbp7kmanbgig3fi
escholarship.org (web)
web.archive.org (webarchive)
Read Archived PDF
Preserved and Accessible
Type  article-journal
Stage   published
Date   2020-04-17
Language   en ?
DOI  10.1002/pro.3873
PubMed  32304108
PMC  PMC7264519
Container Metadata
Not in DOAJ
In Keepers Registry
ISSN-L:  0961-8368
Work Entity
access all versions, variants, and formats of this works (eg, pre-prints)
Catalog Record
Revision: 39067257-fd04-47eb-b170-fcba7babced7
API URL: JSON