12α-hydroxy-<i>N</i>-demethyl-sauroxine, a lycodane type alkaloid from <i>Phlegmariurus saururus</i>
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by
Mariana G. Vallejo, Marcos E. Corzo, María Gabriela Ortega, Alicia Mariel Agnese
2019
Abstract
12α-hydroxy-<i>N</i>-demethyl-sauroxine (<b>1</b>), another new Lycopodium alkaloid from the Lycodane group, was isolated from <i>Phlegmariurus saururus</i> (Lam.) B. Øllg. (Lycopodiaceae). Elucidation of the chemical structure and relative stereochemistry were stated by spectroscopic data and chemical correlation. In addition, the inhibitory activity on acetylcholinesterase for <b>1</b> was determined as well as for <i>N</i>-methyllycodine (<b>2</b>), a derivative with the same nucleus, previously identified in <i>P. saururus</i> (IC<sub>50</sub> = 33.8 ± 0.8 μM and 547.5 ± 0.5 μM, respectively) and <i>N</i>-demethylsauroxine (<b>3</b>) whose inhibition in the actual conditions was better than the previously informed.
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Date 2019-03-11
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