12α-hydroxy-<i>N</i>-demethyl-sauroxine, a lycodane type alkaloid from <i>Phlegmariurus saururus</i> release_nryrkyik7farjhq5avlhio3b3e

by Mariana G. Vallejo, Marcos E. Corzo, María Gabriela Ortega, Alicia Mariel Agnese

Published by Figshare.

2019  

Abstract

12α-hydroxy-<i>N</i>-demethyl-sauroxine (<b>1</b>), another new Lycopodium alkaloid from the Lycodane group, was isolated from <i>Phlegmariurus saururus</i> (Lam.) B. Øllg. (Lycopodiaceae). Elucidation of the chemical structure and relative stereochemistry were stated by spectroscopic data and chemical correlation. In addition, the inhibitory activity on acetylcholinesterase for <b>1</b> was determined as well as for <i>N</i>-methyllycodine (<b>2</b>), a derivative with the same nucleus, previously identified in <i>P. saururus</i> (IC<sub>50</sub> = 33.8 ± 0.8 μM and 547.5 ± 0.5 μM, respectively) and <i>N</i>-demethylsauroxine (<b>3</b>) whose inhibition in the actual conditions was better than the previously informed.
In text/plain format

Archived Files and Locations

application/pdf  1.8 MB
file_onjbt5uqofha5orynkoagiuywi
s3-eu-west-1.amazonaws.com (publisher)
web.archive.org (webarchive)
Read Archived PDF
Preserved and Accessible
Type  article-journal
Stage   published
Date   2019-03-11
Work Entity
access all versions, variants, and formats of this works (eg, pre-prints)
Catalog Record
Revision: 2c59844d-5cf8-40ad-a495-cf0082964b7a
API URL: JSON