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Alternatively Spliced ANLN Isoforms Synergistically Contribute To The Progression of Head and Neck Squamous Cell Carcinoma release_nlzccxg2urdbjey7hqqjbto5da

by Erliang Guo, Xionghui Mao, Lunhua Guo, Changming An, Cong Zhang, Kaibin Song, Guohui Wang, Chunbin Duan, Xiwei Zhang, Xianguang Yang, Zhennan Yuan, Ji Sun (+4 others)

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abstracts[] {'sha1': '609c7b8e6ec7c1895a1a19ea8f1d3d56a3166f93', 'content': '<jats:title>Abstract</jats:title>\n <jats:bold>Background:</jats:bold> Head and neck squamous cell carcinoma (HNSCC) is a common cancer with high mortality. Anilin actin binding protein (ANLN) has been reported to be associated with carcinogenesis in multiple tumors. However, the expression pattern and functional effects of ANLN in HNSCC remains to be unclear.<jats:bold>Methods: </jats:bold>Expression of two major splice variants of ANLN was assessed in HNSCC tissues and cell lines. The functional effects and related mechanisms of ANLN isoforms were investigated in HNSCC <jats:italic>in vitro</jats:italic> and <jats:italic>in vivo</jats:italic>.<jats:bold>Results: </jats:bold>Our results showed that the two primary isoforms of ANLN transcripts ANLN-201 and ANLN-210 were highly expressed in HNSCC tissues and cell lines. Knockout of ANLN restrained cell proliferation, migration and invasion of SCC-9 cells. Mechanically, ANLN-201 could interact with c-Myc to keep its protein stability, thereby playing a oncogenic role in HNSCC. ANLN-210 could be transferred to macrophages via exosomes by binding to RNA binding protein hnRNPC. Exosomal ANLN-210 promoted macrophage polarization via PTEN/PI3K/Akt signaling pathway, thus stimulating tumor growth of HNSCC.<jats:bold>Conclusions: </jats:bold>Our findings demonstrate that alternatively spliced ANLN isoform<jats:bold>s</jats:bold> collaboratively promote HNSCC tumorigenesis <jats:italic>in vitro</jats:italic> and <jats:italic>in vivo</jats:italic>, which might provide the in-depth role and mechanism of ANLN in HNSCC development.', 'mimetype': 'application/xml+jats', 'lang': None}
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contribs[] {'index': 0, 'creator_id': None, 'creator': None, 'raw_name': 'Erliang Guo', 'given_name': 'Erliang', 'surname': 'Guo', 'role': 'author', 'raw_affiliation': 'Harbin Medical College: Harbin Medical University', 'extra': {'seq': 'first'}}
{'index': 1, 'creator_id': None, 'creator': None, 'raw_name': 'Xionghui Mao', 'given_name': 'Xionghui', 'surname': 'Mao', 'role': 'author', 'raw_affiliation': 'Harbin Medical College: Harbin Medical University', 'extra': None}
{'index': 2, 'creator_id': None, 'creator': None, 'raw_name': 'Lunhua Guo', 'given_name': 'Lunhua', 'surname': 'Guo', 'role': 'author', 'raw_affiliation': 'Harbin Medical College: Harbin Medical University', 'extra': None}
{'index': 3, 'creator_id': None, 'creator': None, 'raw_name': 'Changming An', 'given_name': 'Changming', 'surname': 'An', 'role': 'author', 'raw_affiliation': 'Chinese Academy of Medical Sciences Cancer Institute and Hospital: Cancer Hospital Chinese Academy of Medical Sciences', 'extra': None}
{'index': 4, 'creator_id': None, 'creator': None, 'raw_name': 'Cong Zhang', 'given_name': 'Cong', 'surname': 'Zhang', 'role': 'author', 'raw_affiliation': 'Harbin Medical College: Harbin Medical University', 'extra': None}
{'index': 5, 'creator_id': None, 'creator': None, 'raw_name': 'Kaibin Song', 'given_name': 'Kaibin', 'surname': 'Song', 'role': 'author', 'raw_affiliation': 'Harbin Medical College: Harbin Medical University', 'extra': None}
{'index': 6, 'creator_id': None, 'creator': None, 'raw_name': 'Guohui Wang', 'given_name': 'Guohui', 'surname': 'Wang', 'role': 'author', 'raw_affiliation': 'Harbin Medical College: Harbin Medical University', 'extra': None}
{'index': 7, 'creator_id': None, 'creator': None, 'raw_name': 'Chunbin Duan', 'given_name': 'Chunbin', 'surname': 'Duan', 'role': 'author', 'raw_affiliation': 'Harbin Medical College: Harbin Medical University', 'extra': None}
{'index': 8, 'creator_id': None, 'creator': None, 'raw_name': 'Xiwei Zhang', 'given_name': 'Xiwei', 'surname': 'Zhang', 'role': 'author', 'raw_affiliation': 'Chinese Academy of Medical Sciences Cancer Institute and Hospital: Cancer Hospital Chinese Academy of Medical Sciences', 'extra': None}
{'index': 9, 'creator_id': None, 'creator': None, 'raw_name': 'Xianguang Yang', 'given_name': 'Xianguang', 'surname': 'Yang', 'role': 'author', 'raw_affiliation': 'Harbin Medical College: Harbin Medical University', 'extra': None}
{'index': 10, 'creator_id': None, 'creator': None, 'raw_name': 'Zhennan Yuan', 'given_name': 'Zhennan', 'surname': 'Yuan', 'role': 'author', 'raw_affiliation': 'Harbin Medical College: Harbin Medical University', 'extra': None}
{'index': 11, 'creator_id': None, 'creator': None, 'raw_name': 'Ji Sun', 'given_name': 'Ji', 'surname': 'Sun', 'role': 'author', 'raw_affiliation': 'Harbin Medical College: Harbin Medical University', 'extra': None}
{'index': 12, 'creator_id': None, 'creator': None, 'raw_name': 'Xiaomei Li', 'given_name': 'Xiaomei', 'surname': 'Li', 'role': 'author', 'raw_affiliation': 'Harbin Medical College: Harbin Medical University', 'extra': None}
{'index': 13, 'creator_id': None, 'creator': None, 'raw_name': 'Weiwei Yang', 'given_name': 'Weiwei', 'surname': 'Yang', 'role': 'author', 'raw_affiliation': 'Harbin Medical College: Harbin Medical University', 'extra': None}
{'index': 14, 'creator_id': None, 'creator': None, 'raw_name': 'Hongxue Meng', 'given_name': 'Hongxue', 'surname': 'Meng', 'role': 'author', 'raw_affiliation': 'Harbin Medical College: Harbin Medical University', 'extra': None}
{'index': 15, 'creator_id': None, 'creator': None, 'raw_name': 'Susheng Miao', 'given_name': 'Susheng', 'surname': 'Miao', 'role': 'author', 'raw_affiliation': 'Harbin Medical University Third Hospital: Tumor Hospital of Harbin Medical University', 'extra': None}
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release_date 2021-04-05
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release_year 2021
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title Alternatively Spliced ANLN Isoforms Synergistically Contribute To The Progression of Head and Neck Squamous Cell Carcinoma
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