{"DOI":"10.1038/s41598-020-72657-5","PMID":"32973247","abstract":"Abstract\nParvovirus B19 (B19V) occurs globally and can cause severe anaemia. The role of co-infections with Plasmodium falciparum (P. falciparum) has been controversially discussed. The study aimed to determine prevalence and severity of B19V infection, and the effect of co-infections on the risk for anaemia. Between November 2013 and April 2015 a total of 1186 hospital visits of children with fever admitted to a hospital in Ghana were recorded. Malaria, B19V and additional diagnostics for fever causes were performed. Recent B19V infection was defined as PCR and/or IgM positivity. Risk factors for a B19V infection and for anaemia were analysed. The prevalence of anaemia was compared between children with/without B19V infection, stratified for the presence of malaria. B19V\u00a0IgM/PCR was positive in 6.4% (n\u2009=\u200976; 40 IgM\u2009+\u2009, 30 PCR\u2009+\u2009, 6 IgM\u2009+\u2009and PCR\u2009+). Among the B19V cases 60.5% had a simultaneous P. falciparum infection. B19V IgM positivity but not PCR positivity was associated with moderate-severe anaemia (OR\u2009=\u20092.6; 95%-CI: 1.3\u20135.3; P\u2009<\u20090.01 vs. OR\u2009=\u20090.9; 95%-CI: 0.4\u20131.8; P\u2009=\u20090.70). P. falciparum and IgM positive B19V infection were independent risk factors for anaemia with no evidence of effect modification. Our data show a significant association between B19V infection, defined as IgM but not PCR positivity, and moderate-severe anaemia. A multiplicative effect of B19V and P. falciparum infection was not found.","author":[{"family":"Herr","given":"Wiebke"},{"family":"Krumkamp","given":"Ralf"},{"family":"Hogan","given":"Benedikt"},{"family":"Dekker","given":"Denise"},{"family":"Gyau","given":"Kennedy"},{"family":"Owusu-Dabo","given":"Ellis"},{"family":"Sarpong","given":"Nimako"},{"family":"Jaeger","given":"Anna"},{"family":"Loag","given":"Wibke"},{"family":"Winter","given":"Doris"},{"family":"Akenten","given":"Charity Wiafe"},{"family":"Eibach","given":"Daniel"},{"family":"Fickenscher","given":"Helmut"},{"family":"Eis-H\u00fcbinger","given":"Anna"},{"family":"May","given":"J\u00fcrgen"},{"family":"Kreuels","given":"Benno"}],"id":"unknown","issue":"1","issued":{"date-parts":[[2020,9,24]]},"language":"en","page-first":"15695","publisher":"Springer Science and Business Media LLC","title":"A cross-sectional study on risk factors for infection with Parvovirus B19 and the association with anaemia in a febrile paediatric population in Ghana","type":"article-journal","volume":"10"}