2021 Volume 6, Issue 1, p99
<jats:title>Abstract</jats:title>People receiving COVID-19 vaccines may subsequently markedly increase their previously suppressed exposure risk. A simple model can evaluate the benefit of vaccination to the vaccinated (index) person and others exposed to that person; and calculate the amount of risk compensation required to eliminate all the benefits or to halve the benefit. As shown, 2.5-fold increase in exposure will eliminate the benefit of a vaccine of moderate efficacy (<jats:italic>E</jats:italic> = 0.6) unless the probability of infection in the population of interest is very high. With very high vaccine efficacy (<jats:italic>E</jats:italic> = 0.95), substantial benefit is maintained except in situations where there is a very low probability of infection in the population. If the vaccine efficacy decreases to 0.8, the benefit gets eroded easily with modest risk compensation. Risk compensation may markedly affect the benefit of COVID-19 vaccination, especially if vaccine efficacy in real-life or specific high-risk populations (e.g., nursing home residents) is not very high.
Archived Files and Locations
There are no accessible files associated with this release. You could check other releases for this work for an accessible version.
Know of a fulltext copy of on the public web? Submit a URL and we will archive it
Open Access Publication
In ISSN ROAD
In Keepers Registery
access all versions, variants, and formats of this works (eg, pre-prints)