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Development of a Medicare Health Outcomes Survey Deficit-Accumulation Frailty Index and Its Application to Older Patients With Newly Diagnosed Multiple Myeloma release_mz2f4lhn5zgozh4ihoqsyjteca

by Hira S. Mian, Tanya M. Wildes, Mark A. Fiala

Entity Metadata (schema)

abstracts[] {'sha1': '03f8dd9a900fbbd6d5766213bd37d944f2610bc6', 'content': 'To develop a frailty index using the Rockwood Accumulation of Deficits approach for the Medicare Health Outcomes Survey (MHOS) and apply it in a subset of older patients with newly diagnosed multiple myeloma.', 'mimetype': 'text/plain', 'lang': 'en'}
{'sha1': '5a028bf06d51dbcdf8985e7deeaab443c56e426a', 'content': 'Data from 2,692,361 patients without cancer, > 66 years of age, in SEER-MHOS linked databases between 1998 and 2009 were analyzed. A frailty index was constructed, resulting in a 25-item scale; cutoff values were created for individuals classified as frail. This frailty index was then applied to 305 patients with newly diagnosed myeloma in the database to predict overall survival.', 'mimetype': 'text/plain', 'lang': 'en'}
{'sha1': '5848621cdf556e040d6f1d4c00eb620beb4cd336', 'content': 'In the derivation cohort of patients without cancer, the median age was 74 years and the mean frailty index was 0.23 (standard deviation, 0.17). Among patients without cancer, each 10% increase in frailty index (approximately three to four more deficits) was associated with a 40% increased risk for death (adjusted hazard ratio, 1.397; 95% CI, 1.396 to 1.399; P < .001). In the cohort of patients with newly diagnosed myeloma, the median age was 76 years an d the mean frailty index was 0.28 (standard deviation, 0.17). Each 10% increase in frailty index was associated with a 16% increased risk for death (adjusted hazard ratio, 1.159; 95% CI, 1.080 to 1.244; P < .001). Fifty-three percent of patients with multiple myeloma were considered frail. The estimated median overall survival of patients considered frail was 26.8 months, compared with 43.7 months (P = .015) for those who were not.', 'mimetype': 'text/plain', 'lang': 'en'}
{'sha1': 'd617af0d54dd6f98ed66c316785224c332c506ea', 'content': 'The MHOS-based frailty index was prognostic for patients with multiple myeloma in predicting overall survival.', 'mimetype': 'text/plain', 'lang': 'en'}
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release_date 2018-07-25
release_stage published
release_type article-journal
release_year 2018
subtitle
title Development of a Medicare Health Outcomes Survey Deficit-Accumulation Frailty Index and Its Application to Older Patients With Newly Diagnosed Multiple Myeloma
version
volume 2
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As JSON via API

Extra Metadata (raw JSON)

crossref.alternative-id ['10.1200/CCI.18.00043']
crossref.type journal-article
pubmed.pub_types ['Journal Article']