Relaxation‐corrected macromolecular model enables determination of
1
H longitudinal T
1
‐relaxation times and concentrations of human brain metabolites at 9.4T
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Andrew Martin Wright, Saipavitra Murali-Manohar, Tamas Borbath, Nikolai Avdievich, Anke Henning
Abstract
Ultrahigh field MRS has improved characterization of the neurochemical profile. To compare results obtained at 9.4T to those from lower field strengths, it is of interest to quantify the concentrations of metabolites measured. Thus, measuring T1 -relaxation times is necessary to correct for T1 -weighting that occurs in acquisitions for single-voxel spectroscopy and spectroscopic imaging. A macromolecule (MM) simulation model was developed to fit MM contributions to the short TE inversion series used to measure T1 -relaxation times.
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