Relaxation‐corrected macromolecular model enables determination of 1 H longitudinal T 1 ‐relaxation times and concentrations of human brain metabolites at 9.4T release_mnip4ybr5rajxpnj3qtyvpcq7i

by Andrew Martin Wright, Saipavitra Murali-Manohar, Tamas Borbath, Nikolai Avdievich, Anke Henning

Published in Magnetic Resonance in Medicine by Wiley.

2021   Volume 87, Issue 1, p33-49

Abstract

Ultrahigh field MRS has improved characterization of the neurochemical profile. To compare results obtained at 9.4T to those from lower field strengths, it is of interest to quantify the concentrations of metabolites measured. Thus, measuring T1 -relaxation times is necessary to correct for T1 -weighting that occurs in acquisitions for single-voxel spectroscopy and spectroscopic imaging. A macromolecule (MM) simulation model was developed to fit MM contributions to the short TE inversion series used to measure T1 -relaxation times.
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Type  article-journal
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Date   2021-08-10
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DOI  10.1002/mrm.28958
PubMed  34374449
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