Apicobasal polarity and its role in cancer progression release_mk6dzrgohjcqbkb4rn47pju2yq

by Priscilla Lo, Hannah Hawrot, Marios Georgiou

Published in Biomolecular Concepts by Walter de Gruyter GmbH.

2012  

Abstract

<jats:title>Abstract</jats:title>Appropriate establishment and maintenance of cell polarity is essential for normal development and homeostasis. The vast majority of human cancers originate from epithelial tissues and tumour cell invasion and metastasis are the major cause of mortality in human cancers. Invading cells demonstrate loss of cell polarity, loss of epithelial cell-cell adhesions and tissue disorganisation. We examine the growing evidence linking loss of apicobasal polarity with tumour progression.
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Type  article-journal
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Date   2012-01-01
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