Hypoglycemia due to insulin autoimmune syndrome (Hirata's disease): a rare cause of hypoglycaemia release_mj7ia62t7rh5hjqextqizgqiq4

by Het V. Patel, Sunil Kumar, Kalpesh Moradiya, Vidhi Shah

Published in International Journal of Advances in Medicine by Medip Academy.

2021   p1220

Abstract

Although the most common cause of recurrent hypoglycaemia is diabetes mellitus as patient is on antidiabetic medications which can be prevented by modification of antidiabetic doses, nutrition therapy and lifestyle modifications. Some endogenous hyperinsulinemic conditions like insulinoma, functional beta cell disorders and insulin autoimmune syndromes, hormonal deficiencies can cause serious and sometimes life threatening hypoglycaemia. So further laboratory evaluation like plasma/serum glucose levels, c-peptide levels, insulin levels, insulin antibodies and imaging studies are needed to evaluate unexplained hypoglycaemia. Here we report a case of insulin autoimmune syndrome in a 67 year old Indian male who had presented to us with multiple episodes of spontaneous hypoglycaemia. On further workup, the patient was found to have endogenous hyperinsulinemic hypoglycemia. As the patient's abdominal imaging revealed no apparent cause of EHH, on further evaluation he came positive for insulin antibodies. Patient was diagnosed as IAS and he was given frequent small meals and complex carbohydrate diet and he had improved symptomatically. The incidence of IAS is most common in Japan and very few cases have been reported from India, so it should be kept in differential diagnosis of recurrent hypoglycaemia.
In application/xml+jats format

Archived Files and Locations

application/pdf  417.4 kB
file_ahgfibrh2rag5nizbvgsfsvgfa
www.ijmedicine.com (publisher)
web.archive.org (webarchive)
Read Archived PDF
Preserved and Accessible
Type  article-journal
Stage   published
Date   2021-07-23
Journal Metadata
Open Access Publication
Not in DOAJ
In ISSN ROAD
Not in Keepers Registry
ISSN-L:  2349-3925
Work Entity
access all versions, variants, and formats of this works (eg, pre-prints)
Catalog Record
Revision: c55b7b65-a5b5-4d37-82a4-b59473f7a049
API URL: JSON