Pancreatic and Islet Development and Function: The Role of Thyroid Hormone
release_l7logrd7cfd5tl7ls37qi6rlua
by
Teresa L Mastracci, Carmella Evans-Molina
2014 Volume 2, Issue 3
Abstract
A gradually expanding body of literature suggests that Thyroid Hormone (TH) and Thyroid Hormone Receptors (TRs) play a contributing role in pancreatic and islet cell development, maturation, and function. Studies using a variety of model systems capable of exploiting species-specific developmental paradigms have revealed the contribution of TH to cellular differentiation, lineage decisions, and endocrine cell specification. Moreover, in vitro and in vivo evidence suggests that TH is involved in islet β cell proliferation and maturation; however, the signaling pathway(s) connected with this function of TH/TR are not well understood. The purpose of this review is to discuss the current literature that has defined the effects of TH and TRs on pancreatic and islet cell development and function, describe the impact of hyper- and hypothyroidism on whole body metabolism, and highlight future and potential applications of TH in novel therapeutic strategies for diabetes.
In text/plain
format
Archived Files and Locations
application/pdf 362.3 kB
file_t3y2colfd5edfafkrteelbgvxq
|
europepmc.org (repository) web.archive.org (webarchive) |
application/pdf 781.8 kB
file_s5t2j3xnlvgafdumdirtabeksi
|
www.jscimedcentral.com (web) web.archive.org (webarchive) |
access all versions, variants, and formats of this works (eg, pre-prints)