Pancreatic and Islet Development and Function: The Role of Thyroid Hormone release_l7logrd7cfd5tl7ls37qi6rlua

by Teresa L Mastracci, Carmella Evans-Molina

Published in Journal of Endocrinology, Diabetes & Obesity.

2014   Volume 2, Issue 3

Abstract

A gradually expanding body of literature suggests that Thyroid Hormone (TH) and Thyroid Hormone Receptors (TRs) play a contributing role in pancreatic and islet cell development, maturation, and function. Studies using a variety of model systems capable of exploiting species-specific developmental paradigms have revealed the contribution of TH to cellular differentiation, lineage decisions, and endocrine cell specification. Moreover, in vitro and in vivo evidence suggests that TH is involved in islet β cell proliferation and maturation; however, the signaling pathway(s) connected with this function of TH/TR are not well understood. The purpose of this review is to discuss the current literature that has defined the effects of TH and TRs on pancreatic and islet cell development and function, describe the impact of hyper- and hypothyroidism on whole body metabolism, and highlight future and potential applications of TH in novel therapeutic strategies for diabetes.
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Year   2014
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PubMed  25506600
PMC  PMC4261639
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