N'N'-disubstituted piperazine derivatives as antifilarial antiamoebic and spermicidal agents
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U A Sonurlikar, B Shanker, P A Kirke, M B Bhide
1977 Volume 5, Issue 3, p94-6
Abstract
4 derivatives of N',N'-piperazine were tested for spectra of activity against filaria, amoeba, and sperm, in addition to bacteria. All 4 of the desubstituted piperazines stopped movements of sperms within 10 minutes at a concentration of 15.6 mg/ml. 2 of the compounds, coded R-3504 and R-3536, showed activity within 2 minutes. Antifilarial activity was exhibited by all 4 compounds within 5 minutes at 15.6 and 31.2 mg/ml against L. carinii and W. bancroft, respectively, in vitro. 3 of the compounds showed activity against E. histolytica at 5 mg/ml; and R-2916 showed antiamoebal activity at 50 mg/ml in vitro. Up to 200 mg/ml, all 4 compounds exhibited no antibacterial activity against S. typhi, S. aureus, and V. cholerae when tested in vitro. The compounds R-2768, R-3504, and R-3536 inhibited the motility of the microfilariae of W. bancrofti and L. carinii; E. histolyica; and human sperms. This was not due to cytotoxic activity but was specific activity since the compounds did not exhibit any antibacterial activity.
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