Angiogenin, FGF-α, and IL-36β have higher expression levels in aqueous humor of nAMD patients in comparison to cataract patients release_kwov2g7jh5cqdmuwkvza4dkg6a

by Kailin Chen, Wen Xu, Jiao Zheng, Yupeng Shen, Jian Ma, Zhiqing Chen

Published in BMC Ophthalmology by Springer Science and Business Media LLC.

2020   Volume 20, Issue 1, p431

Abstract

<jats:title>Abstract</jats:title> <jats:sec> <jats:title>Background</jats:title> Numerous cytokines have been proven to participate in the pathogenesis of neovascular age-related macular degeneration (nAMD). The present study aimed to investigate the aqueous humor cytokine expression profile in nAMD patients before and after ranibizumab treatments in comparison to cataract patients. </jats:sec> <jats:sec> <jats:title>Methods</jats:title> This prospective study included 20 treatment-naïve nAMD eyes of 20 patients who received three consecutive monthly injections of ranibizumab. Aqueous humor samples were collected before the first (baseline), second (1 month later), and third (2 months later) injections. Controls were 20 age- and gender-matched cataract patients without any other ocular disease. The aqueous concentrations of 28 cytokines were measured using a multiplex bead assay. Central macular thickness (CMT) and maximum retinal thickness (MRT)-3 mm were measured by spectral domain optical coherence tomography (SD-OCT). The greatest linear diameter (GLD) was measured by fundus fluorescein angiography (FA). </jats:sec> <jats:sec> <jats:title>Results</jats:title> Three cytokines in aqueous humor, including angiogenin, interleukin-36β (IL-36β), and fibroblast growth factor-acidic (FGF-α) were significantly higher in nAMD patients in comparison to cataract patients, both before and after two consecutive monthly ranibizumab injections. Compared with the nAMD patients' basal levels, two consecutive monthly ranibizumab injections effectively reduced the aqueous concentrations of VEGF-A and placental growth factor (PlGF), as well as the values of CMT, MRT-3 mm, and GLD. </jats:sec> <jats:sec> <jats:title>Conclusions</jats:title> Angiogenin, IL-36β, and FGF-α have higher expression levels in nAMD patients in comparison to cataract patients, both before and after 2 months of ranibizumab therapy. These cytokines may have correlations with the pathogenesis of nAMD. </jats:sec>
In application/xml+jats format

Archived Files and Locations

application/pdf  675.1 kB
file_vttdnlx6fbhf7peuvmbcv4qa4u
bmcophthalmol.biomedcentral.com (publisher)
web.archive.org (webarchive)
Read Archived PDF
Preserved and Accessible
Type  article-journal
Stage   published
Date   2020-10-28
Language   en ?
Container Metadata
Open Access Publication
In DOAJ
In ISSN ROAD
In Keepers Registry
ISSN-L:  1471-2415
Work Entity
access all versions, variants, and formats of this works (eg, pre-prints)
Catalog Record
Revision: 5630d14e-d8fd-48eb-a54e-9ea203727665
API URL: JSON