Catastrophic Candida prosthetic valve endocarditis and COVID-19 comorbidity: A rare case release_kesf2xvw2bhddbg6ftbxwjv3da

by Lotfollah Davoodi, Leila Faeli, Rogheye Mirzakhani, Rozita Jalalian, Tahereh Shokohi, Firoozeh Kermani

Published in Current Medical Mycology by Knowledge E.

2021   Volume 7, Issue 2, p43-47

Abstract

Background and Purpose: Coronavirus disease 2019 (COVID-19) and Candida prostatic valve endocarditis present various clinical manifestations which may overlap;hence, discrimination between them is extremely difficult.
 Case report: The case was a 66-year-old man with a past medical history of mitral and aortic valves replacement one year before COVID-19 co-infection. He was admitted with fever (for 7 days), shortness of breath, cough, seizure, lethargy,headache, and 85% oxygen saturation. Transesophageal echocardiography revealed multiple large-sized, highly mobile masses on both sides of the mechanical mitral valve highly suggestive of vegetation. Chest computed tomography scanning showed simulating scattered COVID-19 peripheral ground-glass opacities confirmed by reverse-transcription polymerase chain reaction. The set of blood cultures yielded yeast colonies that were identified as Candida tropicalis. The patient died of septic shock shortly after receiving antifungal therapy.
 Conclusion: This case emphasized the importance of early diagnosis and implementation of antifungal treatment, particularly in patients with prosthetic cardiac valves, to reduce their unfavorable outcomes in COVID-19 patients. 
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