{"DOI":"10.1192/bjp.bp.108.052068","PMID":"19721111","abstract":"\n Background\n Structural brain abnormalities have been described in individuals with an at-risk mental state for psychosis. However, the neuroanatomical underpinnings of the early and late at-risk mental state relative to clinical outcome remain unclear.\n \n \n Aims\n To investigate grey matter volume abnormalities in participants in a putatively early or late at-risk mental state relative to their prospective clinical outcome.\n \n \n Method\n Voxel-based morphometry of magnetic resonance imaging data from 20 people with a putatively early at-risk mental state (ARMS\u2013E group) and 26 people with a late at-risk mental state (ARMS\u2013L group) as well as from 15 participants with at-risk mental states with subsequent disease transition (ARMS\u2013T group) and 18 participants without subsequent disease transition (ARMS\u2013NT group) were compared with 75 healthy volunteers.\n \n \n Results\n Compared with healthy controls, ARMS\u2013L participants had grey matter volume losses in frontotemporolimbic structures. Participants in the ARMS\u2013E group showed bilateral temporolimbic alterations and subtle prefrontal abnormalities. Participants in the ARMS\u2013T group had prefrontal alterations relative to those in the ARMS\u2013NT group and in the healthy controls that overlapped with the findings in the ARMS\u2013L group.\n \n \n Conclusions\n Brain alterations associated with the early at-risk mental state may relate to an elevated susceptibility to psychosis, whereas alterations underlying the late at-risk mental state may indicate a subsequent transition to psychosis.\n ","author":[{"family":"Koutsouleris"},{"family":"Schmitt"},{"family":"Gaser"},{"family":"Bottlender"},{"family":"Scheuerecker"},{"family":"McGuire"},{"family":"Burgermeister"},{"family":"Born"},{"family":"Reiser"},{"family":"M\u00f6ller"},{"family":"Meisenzahl"}],"id":"unknown","issue":"03","issued":{"date-parts":[[2009]]},"language":"en","page-first":"218","publisher":"Royal College of Psychiatrists","title":"Neuroanatomical correlates of different vulnerability states for psychosis and their clinical outcomes","type":"article-journal","volume":"195"}